2026-06-14T10:38:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51622024-09-27T08:58:50Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Lee, Peter
author
Calvo, Conrado J.
author
Alfonso-Almazan, Jose M.
author
Quintanilla, Jorge G.
author
Chorro, Francisco J.
author
Yan, Ping
author
Loew, Leslie M.
author
Filgueiras-Rama, David
author
Millet, Jose
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación ProCNIC
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Sociedad Española de Cardiología
funder
Fundación Jesús Serra
funder
Instituto de Salud Carlos III
funder
Generalitat Valenciana (España)
2017-10-20T10:33:49Z
2017-10-20T10:33:49Z
2017
Sci Rep. 2017; 7:43217
10.1038/srep43217
2045-2322
Scientific Reports
28240274
http://hdl.handle.net/20.500.12105/5162
Panoramic optical mapping is the primary method for imaging electrophysiological activity from the entire outer surface of Langendorff-perfused hearts. To date, it is the only method of simultaneously measuring multiple key electrophysiological parameters, such as transmembrane voltage and intracellular free calcium, at high spatial and temporal resolution. Despite the impact it has already had on the fields of cardiac arrhythmias and whole-heart computational modeling, present-day system designs precludes its adoption by the broader cardiovascular research community because of their high costs. Taking advantage of recent technological advances, we developed and validated low-cost optical mapping systems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant model in basic research and bioengineering. By significantly lowering financial thresholds, this powerful cardiac electrophysiology imaging modality may gain wider use in research and, even, teaching laboratories, which we substantiated using the lower-cost Langendorff-perfused rabbit heart model.
eng
3-DIMENSIONAL SURFACE RECONSTRUCTION
PERSISTENT ATRIAL-FIBRILLATION
VENTRICULAR-FIBRILLATION
CARDIAC ELECTROPHYSIOLOGY
EPICARDIAL ACTIVATION
ACTION-POTENTIALS
RABBIT HEART
VOLTAGE
TACHYCARDIA
MECHANISMS
Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models
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