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00925njm 22002777a 4500 dc Lee, Peter author Calvo, Conrado J. author Alfonso-Almazan, Jose M. author Quintanilla, Jorge G. author Chorro, Francisco J. author Yan, Ping author Loew, Leslie M. author Filgueiras-Rama, David author Millet, Jose author 2017 Panoramic optical mapping is the primary method for imaging electrophysiological activity from the entire outer surface of Langendorff-perfused hearts. To date, it is the only method of simultaneously measuring multiple key electrophysiological parameters, such as transmembrane voltage and intracellular free calcium, at high spatial and temporal resolution. Despite the impact it has already had on the fields of cardiac arrhythmias and whole-heart computational modeling, present-day system designs precludes its adoption by the broader cardiovascular research community because of their high costs. Taking advantage of recent technological advances, we developed and validated low-cost optical mapping systems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant model in basic research and bioengineering. By significantly lowering financial thresholds, this powerful cardiac electrophysiology imaging modality may gain wider use in research and, even, teaching laboratories, which we substantiated using the lower-cost Langendorff-perfused rabbit heart model. Sci Rep. 2017; 7:43217 10.1038/srep43217 2045-2322 Scientific Reports 28240274 http://hdl.handle.net/20.500.12105/5162 3-DIMENSIONAL SURFACE RECONSTRUCTION PERSISTENT ATRIAL-FIBRILLATION VENTRICULAR-FIBRILLATION CARDIAC ELECTROPHYSIOLOGY EPICARDIAL ACTIVATION ACTION-POTENTIALS RABBIT HEART VOLTAGE TACHYCARDIA MECHANISMS Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models