2026-07-21T13:56:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51612024-10-31T11:45:02Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
de la Cuesta, Fernando
author
Baldan-Martin, Montserrat
author
Moreno-Luna, Rafael
author
Alvarez-Llamas, Gloria
author
Gonzalez-Calero, Laura
author
Mourino-Alvarez, Laura
author
Sastre-Oliva, Tamara
author
Lopez, Juan Antonio
author
Vazquez, Jesus
author
Ruiz-Hurtado, Gema
author
Segura, Julian
author
Vivanco, Fernando
author
Ruilope, Luis M
author
Barderas, Maria G
funder
Instituto de Salud Carlos III
funder
IDC Salud
funder
Fundación Mutua Madrileña
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2017-10-20T10:33:49Z
2017-10-20T10:33:49Z
2017
Oncotarget. 2017; 8(9):15553-15562
10.18632/oncotarget.14948
1949-2553
Oncotarget
28152519
http://hdl.handle.net/20.500.12105/5161
Despite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin-System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular function are needed to assess patients' condition and help deciding future therapies. Proteomic analysis of circulating extracellular vesicles (EVs) showed two proteins, kalirin and chromodomain-helicase-DNA-binding protein 7 (CHD7), increased in albuminuric patients. A positive correlation of both with the expression of the endothelial activation marker E-selectin was found in EVs. In vitro analysis using TNFa-treated adult human endothelial cells proved their involvement in endothelial cell activation. Hence, we propose protein levels of kalirin and CHD7 in circulating EVs as novel endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria.
eng
Extracellular vesicles
Proteomics
Endothelial dysfunction
Hypertension
Albuminuria
ANGIOTENSIN SYSTEM SUPPRESSION
OXIDATIVE STRESS
CELLS
MICROALBUMINURIA
DISEASE
Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria
journal article
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KalirinAndCHD7Novel_2017
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KalirinAndCHD7Novel_2017_suppl1
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KalirinAndCHD7Novel_2017_suppl2
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KalirinAndCHD7Novel_2017.txt
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KalirinAndCHD7Novel_2017_suppl1.txt
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KalirinAndCHD7Novel_2017_suppl2.txt