2026-05-22T00:02:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51202024-09-27T08:00:36Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Hu, Yao
author
Tanaka, Toshiko
author
Zhu, Jingwen
author
Guan, Weihua
author
Wu, Jason H. Y.
author
Psaty, Bruce M.
author
McKnight, Barbara
author
King, Irena B.
author
Sun, Qi
author
Richard, Melissa
author
Manichaikul, Ani
author
Frazier-Wood, Alexis C.
author
Kabagambe, Edmond K.
author
Hopkins, Paul N.
author
Ordovas, Jose M
author
Ferrucci, Luigi
author
Bandinelli, Stefania
author
Arnett, Donna K
author
Chen, Yii-Der I.
author
Liang, Shuang
author
Siscovick, David S.
author
Tsai, Michael Y.
author
Rich, Stephen S.
author
Fornage, Myriam
author
Hu, Frank
author
Rimm, Eric B.
author
Jensen, Majken K.
author
Lemaitre, Rozenn N
author
Mozaffarian, Dariush
author
Steffen, Lyn M.
author
Morris, Andrew P.
author
Li, Huaixing
author
Lin, Xu
funder
Ministry of Science and Technology (China)
funder
National Natural Science Foundation of China
funder
NIH - Roadmap for Medical Research (Estados Unidos)
funder
University of Alabama at Birmingham (Estados Unidos)
funder
Northwestern University (Estados Unidos)
funder
University of Minnesota (Estados Unidos)
funder
Kaiser Family Foundation
funder
Johns Hopkins University (Estados Unidos)
funder
NIH - National Human Genome Research Institute (NHGRI) (Estados Unidos)
funder
NIH - National Institute of Neurological Disorders and Stroke (NINDS) (Estados Unidos)
funder
NIH - National Institute on Aging (NIA) (Estados Unidos)
funder
National Center for Advancing Translational Sciences (Estados Unidos)
funder
NIH - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (Estados Unidos)
funder
National Institutes of Health (Estados Unidos)
funder
American Diabetes Association
funder
American Heart Association
funder
Ministero della Salute (Italia)
2017-10-20T10:23:12Z
2017-10-20T10:23:12Z
2017
J Lipid Res. 2017; 58(5):974-981
10.1194/jlr.P071860
1539-7262
0022-2275
Journal of Lipid Research
28298293
http://hdl.handle.net/20.500.12105/5120
MUFAs are unsaturated FAs with one double bond and are derived from endogenous synthesis and dietary intake. Accumulating evidence has suggested that plasma and erythrocyte MUFA levels are associated with cardiometabolic disorders, including CVD, T2D, and metabolic syndrome (MS). Previous genome-wide association studies (GWASs) have identified seven loci for plasma and erythrocyte palmitoleic and oleic acid levels in populations of European origin. To identify additional MUFA-associated loci and the potential functional variant at each locus, we performed ethnic-specific GWAS meta-analyses and trans-ethnic meta-analyses in more than 15,000 participants of Chinese and European ancestry. We identified novel genome-wide significant associations for vaccenic acid at FADS1/2 and PKD2L1 [log(10)(Bayes factor). >= 8.07] and for gondoic acid at FADS1/2 and GCKR [log(10)(Bayes factor) >= 6.22], and also observed improved fine-mapping resolutions at FADS1/2 and GCKR loci. The greatest improvement was observed at GCKR, where the number of variants in the 99\% credible set was reduced from 16 (covering 94.8 kb) to 5 (covering 19.6 kb, including a missense variant rs1260326) after trans-ethnic meta-analysis. We also confirmed the previously reported associations of PKD2L1, FADS1/2, GCKR, and HIF1AN with palmitoleic acid and of FADS1/2 and LPCAT3 with oleic acid in the Chinese-specific GWAS and the trans-ethnic meta-analyses. Pathway-based analyses suggested that the identified loci were in unsaturated FA metabolism and signaling pathways.(jl) Our findings provide novel insight into the genetic basis relevant to MUFA metabolism and biology.
eng
Genetics
Fatty acid/desaturases
Fatty acid/metabolism
Fatty acid/biosynthesis
Monounsaturated fatty acid
GENOME-WIDE ASSOCIATION
MONOUNSATURATED FATTY-ACIDS
NOVO LIPOGENESIS PATHWAY
CORONARY-HEART-DISEASE
C-REACTIVE PROTEIN
METABOLIC SYNDROME
OLDER CHINESE
PALMITOLEIC ACID
ADIPOSE-TISSUE
RISK
Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations
journal article
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Discoveryandfine-mappingoflociassociated_2017
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J. Lipid Res.-2017-Hu-974-81(1).pdf.txt
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Discovery and fine-mapping of loci associated_2017.txt
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Discovery and fine-mapping of loci associated_2017.txt
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Discoveryandfine-mappingoflociassociated_2017.txt
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Discoveryandfine-mappingoflociassociated_2017.txt