2026-06-14T03:39:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51172024-09-27T09:10:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Sancho, David
author
Enamorado, Michel
author
Garaude, Johan
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea
funder
Fondation ACTERIA (Acting on European Research in Immunology and Allergology)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación ProCNIC
funder
Institut National de la Santé et de la Recherche Médicale (Francia)
2017-10-20T10:23:11Z
2017-10-20T10:23:11Z
2017
Front Immunol. 2017; 8:527
10.3389/fimmu.2017.00527
1664-3224
Frontiers in Immunology
28533780
http://hdl.handle.net/20.500.12105/5117
Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing immune cell function. Mitochondria are at the core of metabolic adaptation to the changing environment. The close interaction between mitochondrial metabolism and immune signaling has emerged as a central regulator of innate sensing. Metabolic processes generate a constant flow of electrons that eventually end up in the mitochondrial electron transport chain (ETC). Two electron carriers and four respiratory complexes that can assemble as larger molecular supercomplexes compose the ETC in the mitochondrial inner membrane. While the meaning and biological relevance of such structural organization is a matter of passionate debates, recent data support that innate stimuli remodel the ETC. We will review the function of mitochondrial metabolism and ETC dynamics as innate rheostats that regulate signaling, transcription, and epigenetics to orchestrate innate immune responses.
eng
Innate immune response
Immunometabolism
Electron transport chain
Mitochondria
Macrophages
Dendritic cells
Cytokines
Inflammation
NLRP3 INFLAMMASOME ACTIVATION
DENDRITIC CELL ACTIVATION
HOST-DEFENSE
MYCOBACTERIUM-TUBERCULOSIS
MACROPHAGE POLARIZATION
SUCCINATE-DEHYDROGENASE
ALTERNATIVE ACTIVATION
PYRUVATE-DEHYDROGENASE
BACTERICIDAL ACTIVITY
TRAINED IMMUNITY
Innate Immune Function of Mitochondrial Metabolism
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InnateImmuneFunctionOfMitochondrial_2017.txt
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InnateImmuneFunctionOfMitochondrial_2017.txt