2026-04-29T00:59:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51102024-09-27T10:00:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Bicker, Frank
author
Vasic, Verica
author
Horta, Guilherme
author
Ortega, Felipe
author
Nolte, Hendrik
author
Kavyanifar, Atria
author
Keller, Stefanie
author
Stankovic, Nevenka Dudvarski
author
Harter, Patrick N.
author
Benedito, Rui
author
Lutz, Beat
author
Baeuerle, Tobias
author
Hartwig, Jens
author
Baumgart, Jan
author
Krueger, Marcus
author
Radyushkin, Konstantin
author
Alberi, Lavinia
author
Berninger, Benedikt
author
Schmidt, Mirko H. H.
funder
Deutsche Forschungsgemeinschaft (Alemania)
2017-10-20T10:23:11Z
2017-10-20T10:23:11Z
2017
Nat Commun. 2017; 8:15922
2041-1723
http://hdl.handle.net/20.500.12105/5110
28656980
10.1038/ncomms15922
Nature Communications
Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell niche. Loss of EGFL7 causes an accumulation of activated NSCs, which display enhanced activity and re-entry into the cell cycle. EGFL7 pushes activated NSCs towards quiescence and neuronal progeny towards differentiation. This is achieved by promoting Dll4-induced Notch signalling at the blood vessel-stem cell interface. Fewer inhibitory neurons form in the OB of EGFL7-knockout mice, which increases the absolute signal conducted from the mitral cell layer of the OB but decreases neuronal network synchronicity. Consequently, EGFL7-knockout mice display severe physiological defects in olfactory behaviour and perception.
eng
NEURAL STEM-CELLS
IN-VIVO
SUBEPENDYMAL ZONE
STIMULATES NEUROGENESIS
LINEAGE PROGRESSION
ENDOTHELIAL-CELLS
SELF-RENEWAL
BRAIN
NICHE
MOUSE
Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception
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