2026-04-29T04:10:13Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/51102024-09-27T10:00:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Bicker, Frank author Vasic, Verica author Horta, Guilherme author Ortega, Felipe author Nolte, Hendrik author Kavyanifar, Atria author Keller, Stefanie author Stankovic, Nevenka Dudvarski author Harter, Patrick N. author Benedito, Rui author Lutz, Beat author Baeuerle, Tobias author Hartwig, Jens author Baumgart, Jan author Krueger, Marcus author Radyushkin, Konstantin author Alberi, Lavinia author Berninger, Benedikt author Schmidt, Mirko H. H. author 2017 Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell niche. Loss of EGFL7 causes an accumulation of activated NSCs, which display enhanced activity and re-entry into the cell cycle. EGFL7 pushes activated NSCs towards quiescence and neuronal progeny towards differentiation. This is achieved by promoting Dll4-induced Notch signalling at the blood vessel-stem cell interface. Fewer inhibitory neurons form in the OB of EGFL7-knockout mice, which increases the absolute signal conducted from the mitral cell layer of the OB but decreases neuronal network synchronicity. Consequently, EGFL7-knockout mice display severe physiological defects in olfactory behaviour and perception. Nat Commun. 2017; 8:15922 2041-1723 http://hdl.handle.net/20.500.12105/5110 28656980 10.1038/ncomms15922 Nature Communications NEURAL STEM-CELLS IN-VIVO SUBEPENDYMAL ZONE STIMULATES NEUROGENESIS LINEAGE PROGRESSION ENDOTHELIAL-CELLS SELF-RENEWAL BRAIN NICHE MOUSE Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception