2026-06-14T10:38:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51052024-11-29T08:20:01Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16968
Repisalud
author
Enamorado, Michel
author
Iborra, Salvador
author
Priego, Elena
author
Cueto, Francisco J.
author
Quintana, Juan A.
author
Martinez-Cano, Sarai
author
Mejias-Perez, Ernesto
author
Esteban, Mariano
author
Melero, Ignacio
author
Hidalgo, Andres
author
Sancho, David
funder
Asociación Española Contra el Cáncer
funder
Fundación BBVA
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fondation ACTERIA (Acting on European Research in Immunology and Allergology)
funder
Unión Europea. Comisión Europea
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Fundación ProCNIC
2017-10-20T10:23:10Z
2017-10-20T10:23:10Z
2017
Nat Commun. 2017; 8:16073
10.1038/ncomms16073
2041-1723
NATURE COMMUNICATIONS
28714465
http://hdl.handle.net/20.500.12105/5105
The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8(+) T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8(+) T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8(+) T cells subsets needed for optimal tumour vaccination and immunotherapy.
eng
TUMOR-INFILTRATING LYMPHOCYTES
CD8-ALPHA(+) DENDRITIC CELLS
TISSUE-RESIDENT
NONLYMPHOID TISSUE
VIRAL-INFECTION
RESPONSES
REVEALS
CANCER
IL-12
EXPRESSION
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells
journal article
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EnhancedAnti-tumourImmunity_2017
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text/plain
EnhancedAnti-tumourImmunity_2017.txt
URL
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MD5
7618bd696c0b7d7f03b6aeef4d433adf
58555
text/plain
EnhancedAnti-tumourImmunity_2017.txt