2026-06-14T05:05:17Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/51052024-11-29T08:20:01Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16968

00925njm 22002777a 4500 dc Enamorado, Michel author Iborra, Salvador author Priego, Elena author Cueto, Francisco J. author Quintana, Juan A. author Martinez-Cano, Sarai author Mejias-Perez, Ernesto author Esteban, Mariano author Melero, Ignacio author Hidalgo, Andres author Sancho, David author 2017 The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8(+) T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8(+) T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8(+) T cells subsets needed for optimal tumour vaccination and immunotherapy. Nat Commun. 2017; 8:16073 10.1038/ncomms16073 2041-1723 NATURE COMMUNICATIONS 28714465 http://hdl.handle.net/20.500.12105/5105 TUMOR-INFILTRATING LYMPHOCYTES CD8-ALPHA(+) DENDRITIC CELLS TISSUE-RESIDENT NONLYMPHOID TISSUE VIRAL-INFECTION RESPONSES REVEALS CANCER IL-12 EXPRESSION Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells