2026-04-29T17:03:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/51042024-09-27T08:23:24Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Caja, Sergio
author
Enriquez, Jose Antonio
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Fundación ProCNIC
2017-10-20T10:23:10Z
2017-10-20T10:23:10Z
2017
Redox Biol. 2017; 12:821-827
10.1016/j.redox.2017.04.021
2213-2317
Redox Biology
28448943
http://hdl.handle.net/20.500.12105/5104
The involvement of angiogenesis in disease and its potential as a therapeutic target have been firmly established over recent decades. Endothelial cells (ECs) are central elements in vessel homeostasis and regulate the passage of material and cells into and out of the bloodstream. EC proliferation and migration are modified by alterations to mitochondrial biogenesis and dynamics resulting from several signals and environmental cues, such as oxygen, hemodynamics, and nutrients. As intermediary signals, mitochondrial ROS are released as important downstream modulators of the expression of angiogenesis-related genes. In this review, we discuss the physiological actions of these signals and aberrant responses during vascular disorders.
eng
Endothelial cells
Mitochondria
Biogenesis
Dynamics
ROS
DYNAMIN-RELATED PROTEIN-1
VASCULAR SMOOTH-MUSCLE
LAMINAR SHEAR-STRESS
BLOOD-BRAIN-BARRIER
OXYGEN SPECIES ROS
OXIDATIVE STRESS
ANGIOTENSIN-II
NITRIC-OXIDE
CARDIOVASCULAR-SYSTEM
ADHESION MOLECULE-1
Mitochondria in endothelial cells: Sensors and integrators of environmental cues
journal article
URL
https://repisalud.isciii.es/bitstreams/d828f592-65b6-4d40-b1a8-45ade64ccd27/download
File
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application/pdf
MitochondriaInEndothelialCells_2017
URL
https://repisalud.isciii.es/bitstreams/e622017f-534f-4a72-9be0-5eb7f6d6fd77/download
File
MD5
0816fc8d11374c8ae84a4a6aa12d3f60
53095
text/plain
MitochondriaInEndothelialCells_2017.txt