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oai:repisalud.isciii.es:20.500.12105/51042024-09-27T08:23:24Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Caja, Sergio author Enriquez, Jose Antonio author 2017 The involvement of angiogenesis in disease and its potential as a therapeutic target have been firmly established over recent decades. Endothelial cells (ECs) are central elements in vessel homeostasis and regulate the passage of material and cells into and out of the bloodstream. EC proliferation and migration are modified by alterations to mitochondrial biogenesis and dynamics resulting from several signals and environmental cues, such as oxygen, hemodynamics, and nutrients. As intermediary signals, mitochondrial ROS are released as important downstream modulators of the expression of angiogenesis-related genes. In this review, we discuss the physiological actions of these signals and aberrant responses during vascular disorders. Redox Biol. 2017; 12:821-827 10.1016/j.redox.2017.04.021 2213-2317 Redox Biology 28448943 http://hdl.handle.net/20.500.12105/5104 Endothelial cells Mitochondria Biogenesis Dynamics ROS DYNAMIN-RELATED PROTEIN-1 VASCULAR SMOOTH-MUSCLE LAMINAR SHEAR-STRESS BLOOD-BRAIN-BARRIER OXYGEN SPECIES ROS OXIDATIVE STRESS ANGIOTENSIN-II NITRIC-OXIDE CARDIOVASCULAR-SYSTEM ADHESION MOLECULE-1 Mitochondria in endothelial cells: Sensors and integrators of environmental cues