2026-04-29T12:23:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/50992024-10-31T11:51:24Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Martin-Lorenzo, Marta
author
Gonzalez-Calero, Laura
author
Martinez, Paula J.
author
Baldan-Martin, Montserrat
author
Lopez, Juan Antonio
author
Ruiz-Hurtado, Gema
author
de la Cuesta, Fernando
author
Segura, Julian
author
Vazquez, Jesus
author
Vivanco, Fernando
author
Barderas, Maria G
author
Ruilope, Luis M
author
Alvarez-Llamas, Gloria
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación SENEFRO
2017-10-20T10:23:09Z
2017-10-20T10:23:09Z
2017
Sci Rep. 2017; 7(1):8894
10.1038/s41598-017-09042-2
2045-2322
Scientific reports
28827575
http://hdl.handle.net/20.500.12105/5099
Albuminuria development in hypertensive patients is an indicator of higher cardiovascular (CV) risk and renal damage. Chronic renin-angiotensin system (RAS) suppression facilitates blood pressure control but it does not prevent from albuminuria development. We pursued the identification of protein indicators in urine behind albuminuria development in hypertensive patients under RAS suppression. Urine was collected from 100 patients classified in three groups according to albuminuria development: (a) patients with persistent normoalbuminuria; (b) patients developing de novo albuminuria; (c) patients with maintained albuminuria. Quantitative analysis was performed in a first discovery cohort by isobaric labeling methodology. Alterations of proteins of interest were confirmed by target mass spectrometry analysis in an independent cohort. A total of 2416 proteins and 1223 functional categories (coordinated protein responses) were identified. Immune response, adhesion of immune and blood cells, and phagocytosis were found significantly altered in patients with albuminuria compared to normoalbuminuric individuals. The complement system C3 increases, while Annexin A1, CD44, S100A8 and S100A9 proteins showed significant diminishment in their urinary levels when albuminuria is present. This study reveals specific links between immune response and controlled hypertension in patients who develop albuminuria, pointing to potential protein targets for novel and future therapeutic interventions.
eng
CHRONIC KIDNEY-DISEASE
COMPLEMENT C3
QUANTITATIVE PROTEOMICS
NONDIABETIC INDIVIDUALS
PEPTIDE IDENTIFICATION
ARTERIAL-HYPERTENSION
MICROALBUMINURIA
INFLAMMATION
PROTEIN
PLASMA
Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria
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