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oai:repisalud.isciii.es:20.500.12105/48402025-04-03T17:22:45Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978
Repisalud author Guzman-Fulgencio, Maria author Berenguer, Juan author Jimenez-Sousa, Maria Angeles author Pineda-Tenor, Daniel author Aldámiz-Echevarria, Teresa author Garcia-Broncano, Pilar author Carrero, Ana author Garcia-Alvarez, Monica author Tejerina, Francisco author Díez, Cristina author Vázquez-Morón, Sonia author Resino, Salvador funder Fundación para la Investigación y la Prevención del Sida en España funder Instituto de Salud Carlos III funder Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 2017-09-04T16:32:51Z 2017-09-04T16:32:51Z 2015-06-30 J Transl Med. 2015;13:206 10.1186/s12967-015-0577-y 1479-5876 Journal of Translational Medicine 26123260 http://hdl.handle.net/20.500.12105/4840 Background: Interleukin-7 (IL-7) is a critical factor for T cell development and for maintaining and restoring homeostasis of mature T cells. Polymorphisms at α-chain of the IL-7 receptor (IL7R or CD127) gene are related to evolution of HIV-infection, but there are no data concerning the evolution of hepatitis C virus (HCV) infection. The aim of this study was to analyze the association between IL7R polymorphisms and severe liver disease in HCV/HIV coinfected patients. Methods: We performed a cross-sectional study in 220 naïve patients who underwent a liver biopsy. IL7R polymorphisms (rs6897932, rs987106 and rs3194051) were genotyped using the GoldenGate(®) assay. The outcome variables were: (a) liver biopsy: advanced fibrosis (F ≥ 3), severe activity grade (A3); (b) non-invasive indexes: advanced fibrosis (APRI ≥1.5 and FIB-4 ≥3.25). Logistic regression analysis was used to investigate the association between IL7R polymorphisms and outcome variables. This test gives the differences between groups and the odds ratio (OR) for liver disease. Results: Patients with rs6897932 CC genotype had higher likelihood of having A3 than patients with rs6897932 CT/TT (adjusted odds ratio (aOR) = 4.16; p = 0.026). Patients with rs987106 TT genotype had higher odds of having F ≥ 3 (aOR = 3.09; p = 0.009) than rs987106 AA/AT carriers. Finally, patients with rs3194051 AA genotype had higher odds of having severe liver fibrosis (F ≥ 3; APRI ≥1.5, and FIB4 ≥3.25) than patients with rs3194051 AG/GG genotype [aOR = 2.73 (p = 0.010); aOR = 2.52 (p = 0.029); and aOR = 4.01 (p = 0.027); respectively]. The CTA haplotype (comprised of rs6897932, rs987106, and rs3194051) carriers had higher odds of having F ≥ 3 (aOR = 1.85; p = 0.012), APRI ≥1.5 (aOR = 1.94; p = 0.023), and FIB4 ≥3.25 (aOR = 2.47; p = 0.024). Conversely, the CAG haplotype carriers had lower odds of having F ≥ 3 (aOR = 0.48; p = 0.011), APRI ≥1.5 (aOR = 0.48; p = 0.029), and FIB4 ≥3.25 (aOR = 0.29; p = 0.010). Conclusions: The presence of IL7R polymorphisms seems to be related to severe liver disease in HIV/HCV coinfected patients, because patients with unfavorable IL7R genotypes (rs6897932 CC, rs987106 TT, and rs3194051AA) had a worse prognosis of CHC. eng HIV/AIDS Hepatic fibrosis Chronic hepatitis C IL7R SNPs Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study research article URL https://repisalud.isciii.es/bitstreams/736ad213-40bb-49b0-8af9-b43e01d091a7/download File MD5 80989976d3e2829a13f6c65539ac31b3 1042879 application/pdf AssociationBetweenIL7RPolymorphisms_2015.pdf URL https://repisalud.isciii.es/bitstreams/4eb4d593-2342-4c91-8a92-76ea3b41638c/download File MD5 8e8526406170a1ab49b8c51d39df6407 45665 text/plain 12967_2015_Article_577.pdf.txt URL https://repisalud.isciii.es/bitstreams/b5358666-566e-4709-86ef-4e52fccfc6a1/download File MD5 8e8526406170a1ab49b8c51d39df6407 45665 text/plain AssociationBetweenIL7RPolymorphisms_2015.pdf.txt URL https://repisalud.isciii.es/bitstreams/102a9e4e-a49f-4067-b229-82444a8db876/download File MD5 8e8526406170a1ab49b8c51d39df6407 45665 text/plain AssociationBetweenIL7RPolymorphisms_2015.pdf.txt