2026-04-28T22:57:03Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/48162025-05-05T12:28:41Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud author Dierssen-Sotos, Trinidad author Gómez-Acebo, Inés author de Pedro, María author Perez-Gomez, Beatriz author Servitja, Sonia author Moreno, Victor author Amiano, Pilar author Fernandez-Villa, Tania author Barricarte, Aurelio author Tardón, Adonina author Diaz-Santos, Marian author Peiró-Pérez, Rosana author Marcos-Gragera, Rafael author Lope Carvajal, Virginia author Gràcia-Lavedan, Esther author Alonso, María Henar author Michelena-Echeveste, Maria Jesus author Garcia-Palomo, Andrés author Guevara, Marcela author Castaño-Vinyals, Gemma author Aragones, Nuria author Kogevinas, Manolis author Pollan-Santamaria, Marina author Llorca, Javier funder Instituto de Salud Carlos III funder Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) funder Fundación Marqués de Valdecilla funder International Cancer Genome Consortium funder Ministerio de Economía y Competitividad (España) funder Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) funder Junta de Castilla y León (España) funder Regional Government of Andalusia (España) funder Basque Government (España) funder Fundación La Caixa funder Asociación Española Contra el Cáncer funder Government of Catalonia (España) 2017-09-04T16:29:01Z 2017-09-04T16:29:01Z 2016-08-20 BMC Cancer. 2016; 16: 660 http://hdl.handle.net/20.500.12105/4816 27542890 10.1186/s12885-016-2692-4 1471-2407 BMC Cancer BACKGROUND: The relationship between non-steroidal antiinflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported that NSAID consumption protected against breast cancer, while most cohort studies did not find this effect. Most studies have dealt with NSAIDs as a whole group or with specific drugs, such aspirin, ibuprofen, or others, but not with NSAID subgroups according to the Anatomical Therapeutic Chemical Classification System; moreover, scarce attention has been paid to their effect on different tumor categories (i.e.: ductal/non-ductal, stage at diagnosis or presence of hormonal receptors). METHODS: In this case-control study, we report the NSAID - breast cancer relationship in 1736 breast cancer cases and 1895 healthy controls; results are reported stratifying by the women's characteristics (i.e.: menopausal status or body mass index category) and by tumor characteristics. RESULTS: In our study, NSAID use was associated with a 24 % reduction in breast cancer risk (Odds ratio [OR] = 0.76; 95 % Confidence Interval [CI]: 0.64-0.89), and similar results were found for acetic acid derivatives, propionic acid derivatives and COXIBs, but not for aspirin. Similar results were found in postmenopausal and premenopausal women. NSAID consumption also protected against hormone + or HER2+ cancers, but not against triple negative breast cancers. The COX-2 selectivity showed an inverse association with breast cancer (i.e. OR < 1), except in advanced clinical stage and triple negative cancers. CONCLUSION: Most NSAIDs, but not aspirin, showed an inverse association against breast cancer; this effect seems to be restricted to hormone + or HER2+ cancers. eng Breast cancer Non-steroidal anti-inflammatory drug Hormone receptor positive breast cancer HER2 positive breast cancer Triple negative breast cancer Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study research article URL https://repisalud.isciii.es/bitstreams/507480b1-ac2c-407d-b3a1-e449356b7404/download File MD5 6df26dc64d61a9e6819b7987e59263fb 473043 application/pdf UseOfNonSteroidal_2016.pdf URL https://repisalud.isciii.es/bitstreams/7da531e3-1a80-4788-adbb-544646071ec2/download File MD5 f18fd2f850495e50947e30d811074a30 51806 text/plain 12885_2016_Article_2692.pdf.txt URL https://repisalud.isciii.es/bitstreams/0af325f1-078a-45eb-b1c2-1c5480c8bcb9/download File MD5 f18fd2f850495e50947e30d811074a30 51806 text/plain UseOfNonSteroidal_2016.pdf.txt