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oai:repisalud.isciii.es:20.500.12105/48082024-11-14T21:04:29Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud author Díez-Domingo, Javier author Pérez-Yarza, Eduardo G author Melero, Jose Antonio author Sánchez-Luna, Manuel author Aguilar, María Dolores author Blasco, Antonio Javier author Alfaro, Noelia author Lázaro, Pablo funder AbbVie 2017-09-04T16:27:44Z 2017-09-04T16:27:44Z 2014-10-30 BMC Infect Dis. 2014; 14: 544 10.1186/s12879-014-0544-x 1471-2334 BMC Infectious Diseases 25358423 http://hdl.handle.net/20.500.12105/4808 BACKGROUND: Bronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital heart disease, or bronchopulmonary dysplasia, as well as in immunosuppressed infants. There is a rich literature on the different aspects of RSV infection with a focus, for the most part, on specific risk populations. However, there is a need for a systematic global analysis of the impact of RSV infection in terms of use of resources and health impact on both children and adults. With this aim, we performed a systematic search of scientific evidence on the social, economic, and health impact of RSV infection. METHODS: A systematic search of the following databases was performed: MEDLINE, EMBASE, Spanish Medical Index, MEDES-MEDicina in Spanish, Cochrane Plus Library, and Google without time limits. We selected 421 abstracts based on the 6,598 articles identified. From these abstracts, 4 RSV experts selected the most relevant articles. They selected 65 articles. After reading the full articles, 23 of their references were also selected. Finally, one more article found through a literature information alert system was included. RESULTS: The information collected was summarized and organized into the following topics: 1. Impact on health (infections and respiratory complications, mid- to long-term lung function decline, recurrent wheezing, asthma, other complications such as otitis and rhino-conjunctivitis, and mortality; 2. Impact on resources (visits to primary care and specialists offices, emergency room visits, hospital admissions, ICU admissions, diagnostic tests, and treatments); 3. Impact on costs (direct and indirect costs); 4. Impact on quality of life; and 5. Strategies to reduce the impact (interventions on social and hygienic factors and prophylactic treatments). CONCLUSIONS: We concluded that 1. The health impact of RSV infection is relevant and goes beyond the acute episode phase; 2. The health impact of RSV infection on children is much better documented than the impact on adults; 3. Further research is needed on mid- and long-term impact of RSV infection on the adult population, especially those at high-risk; 4. There is a need for interventions aimed at reducing the impact of RSV infection by targeting health education, information, and prophylaxis in high-risk populations. eng Respiratory syncytial virus Social impact Health impact Social, economic, and health impact of the respiratory syncytial virus: a systematic search journal article URL https://repisalud.isciii.es/bitstreams/b23332ce-b5ab-4b57-89b9-949f13786b46/download File MD5 7b2d26e4d065f894a401ad2d62225a6d 309781 application/pdf SocialEconomicAndHealth_2014.pdf URL https://repisalud.isciii.es/bitstreams/782d2296-489a-4431-a0fa-6c41b1cbc37a/download File MD5 2786b35d0115c1b990f13e3e908e7101 79165 text/plain 12879_2014_Article_544.pdf.txt URL https://repisalud.isciii.es/bitstreams/1808a25b-e8e0-4925-9afc-8105fa589de4/download File MD5 2786b35d0115c1b990f13e3e908e7101 79165 text/plain SocialEconomicAndHealth_2014.pdf.txt URL https://repisalud.isciii.es/bitstreams/3ddc7351-01d9-4deb-a38e-5eb8ecde4768/download File MD5 2786b35d0115c1b990f13e3e908e7101 79165 text/plain SocialEconomicAndHealth_2014.pdf.txt