2026-10-27T19:20:33Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/277862026-10-27T01:16:15Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609

00925njm 22002777a 4500 dc Berenguer, Juan author Jarrin Vera, Inmaculada author Bellón, José M author Díez, Cristina author Jimenez-Sousa, Maria Angeles author Roca, Cristina author González-García, Juan author Dalmau, David author Olalla, Julián author Herrero, Carmen author Villarroya, Francesc author Domingo, Pere author Resino, Salvador author 2023-03-21 Background: We studied the association of obesity-related single-nucleotide polymorphisms (OR-SNPs) with weight gain after antiretroviral therapy (ART) in people with human immunodeficiency virus (HIV; PWH). Methods: Participants were ART-naive PWH from the Spanish HIV Research Cohort who started ART from 2014 onward and had blood/DNA deposited in the cohort Biobank. The primary outcome was change in weight at 96 weeks after starting ART. We genotyped 14 OR-SNPs from a meta-analysis of genome-wide association studies of body mass index (BMI) loci. Changes over time in weight and BMI were studied using adjusted linear mixed models. Results: A total of 1021 PWH were included. The mean weight gain over 96 weeks was 2.90 (95% confidence interval, 2.54-3.26) kg. Factors associated with higher weight gain were female sex, birth in sub-Saharan Africa, prior AIDS, CD4+ <200 cells/µL, HIV-RNA >100 000 copies/mL, negative hepatitis C virus serology, and use of tenofovir alafenamide. A significant association was found between ZC3H4 rs3810291 GG genotype and BCDIN3D/FAIM2 rs7138803 GG genotype polymorphisms and weight and BMI increase. The estimated adjusted mean (standard error [SE]) of weight gain was 4.26 (0.56) kg in ZC3H4 rs3810291 GG carriers and 2.66 (0.19) kg in AA/AG carriers (P = .007). Likewise the estimated weight gain at 96 weeks was 3.35 (0.29) kg in BCDIN3D/FAIM2 rs7138803 GG carriers and 2.51 (0.24) kg in AG/AA carriers (P = .020). Conclusions: Genetic factors may play a role in weight gain after ART initiation. Further work is needed to replicate our findings and understand how the identified SNPs lead to higher weight gain in this context. Juan Berenguer, Inmaculada Jarrín, José M Bellón, Cristina Díez, María A Jiménez-Sousa, Cristina Roca, Juan González-García, David Dalmau, Julián Olalla, Carmen Herrero, Francesc Villarroya, Pere Domingo, Salvador Resino, Obesity-Related Single-Nucleotide Polymorphisms and Weight Gain Following First-Line Antiretroviral Therapy, Clinical Infectious Diseases, Volume 76, Issue 6, 15 March 2023, Pages 977–985, https://doi.org/10.1093/cid/ciac880 https://hdl.handle.net/20.500.12105/27786 36345912 10.1093/cid/ciac880 1537-6591 Clinical Infectious Diseases HIV Antiretroviral therapy Genetics Obesity Weight gain Obesity-Related Single-Nucleotide Polymorphisms and Weight Gain Following First-Line Antiretroviral Therapy.