2026-10-18T20:56:43Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/277592026-10-15T00:17:17Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Martinez-Campanario, M C author Cortés, Marlies author Han, Lu author Brischetto, Agnese author Rivero-Soriano, Paloma author Font-Díaz, Joan author Maurel, Joan author Andrés, Vicente author Postigo, Antonio author 2025-12 This review explores the dual roles of lipid-laden macrophages (LL-Macs) in inflammation, atherosclerosis and cancer, emphasizing both their shared and divergent functions across physiological and pathological conditions. Lipid metabolism regulates the polarization of macrophages in homeostasis and inflammation. In atherosclerosis, LL-Macs contribute to plaque formation and inflammation, while in cancer, LL-Macs play crucial roles in immune suppression and tumor progression. The article outlines the molecular mechanisms driving macrophage lipid accumulation in each of these scenarios and how the process is influenced by the distinct local microenvironments in inflammation, atherosclerosis and cancer. Single-cell RNA sequencing (scRNA-seq) studies have identified both common and unique gene signatures between LL-Macs in atherosclerosis and cancer, reflecting the varying microenvironmental cues that shape macrophage function and disease outcomes. Finally, we examine lipid-modulating strategies in atherosclerosis, assess their potential in cancer treatment, and highlight research gaps for developing new LL-Macs targeted therapies in cancer. Semin Cancer Biol. 2025 Dec:117:38-56. https://hdl.handle.net/20.500.12105/27759 41005549 10.1016/j.semcancer.2025.09.007 1096-3650 Seminars in cancer biology Atherosclerosis Cancer Immunosuppression Lipid metabolism Lipid-laden macrophages Tumor-associated macrophages Lipid-laden macrophages in atherosclerosis and cancer.