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oai:repisalud.isciii.es:20.500.12105/277512026-10-06T00:17:42Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc Deygas, Mathieu author Bernard, Mathilde author Nivoit, Pierre author De Belly, Henry author Deslys, Alexandre author Jakuszeit, Theresa author Cuvelier, Damien author Garcia-Gomez, Moira author Barbier, Lucie author Wang, Li author Maurin, Mathieu author Tejerina, Emmanuel author Baaziz, Oumaima author Terriac, Emmanuel author Attia, Rafaele author Kniazeva, Anna author Garbay, Serge author Ortega-Zapero, Marina author Saez, Angela author Gomez-Bris, Raquel author Gonzalo, Pilar author Gonzalez-Granado, Jose M author Andrés, Vicente author Weiner, Orion D author Lennon-Duménil, Ana-Maria author Duménil, Guillaume author Piel, Matthieu author Vargas, Pablo author 2026-09-04 To reach inflamed tissues, neutrophils must traverse capillaries as narrow as 2 micrometers. However, how they do so without compromising blood flow or capillary function has remained unclear. By combining intravital live-cell imaging with biomimetic microdevices, we show that neutrophils maintain migration speed in capillaries across increasing levels of confinement. This behavior was not shared by other leukocytes and was independent of nuclear properties. Instead, confinement rapidly engaged Rho-dependent actomyosin contractility at the cell rear, thereby offsetting the increased mechanical resistance imposed by confinement. Disrupting this adaptive response caused neutrophil jamming and eventual occlusion of confined capillary-like networks. These findings identify a neutrophil-intrinsic mechanism that couples capillary confinement to rapid migratory adaptation, helping preserve vascular patency and potentially limiting tissue dysfunction during inflammation. Sci Immunol. 2026 Sep 4;11(123):eaea1426. https://hdl.handle.net/20.500.12105/27751 42696606 10.1126/sciimmunol.aea1426 2470-9468 Science immunology Adaptive motility enables neutrophils to rapidly navigate confined capillaries.