2026-10-13T14:53:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/277492026-10-03T00:16:46Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Andrés, Vicente
author
Fernández-Alvira, Juan M
author
Dorado, Beatriz
author
Guío-Carrión, Ana
author
García-Álvarez, Ana
author
García-Lunar, Inés
author
Fernández-Ortiz, Antonio
author
Fuster, José J
author
Pocock, Stuart
author
Ibáñez, Borja
author
Blasco, María A
author
Fuster, Valentín
2026-10-02T16:08:44Z
2026-10-02T16:08:44Z
2026-05-27
Geroscience. 2026 May 27. doi: 10.1007/s11357-026-02322-8
https://hdl.handle.net/20.500.12105/27749
42201470
10.1007/s11357-026-02322-8
2509-2723
GeroScience
Subclinical atherosclerosis (SA) burden and progression are independently associated with all-cause mortality. However, monitoring SA progression requires reliable and cost-effective biomarkers. While leukocyte telomere length (LTL) attrition has been linked to cardiovascular disease and mortality, it remains uncertain whether changes in LTL over time can predict SA progression. In this study, we conducted a longitudinal study to assess whether accelerated LTL attrition is associated with SA progression over a 6-year period in healthy middle-aged individuals. LTL was measured by high-throughput quantitative fluorescence in-situ hybridization in peripheral-blood leukocyte samples obtained 6 years apart from a sub-cohort of 1068 Progression of Early Subclinical Atherosclerosis (PESA)-study participants. SA was assessed by 3D vascular ultrasound in the carotid and femoral territories. Associations were evaluated using linear and logistic regression models. LTL parameters at baseline and after 6 years showed a positive correlation, but no significant associations were found between changes in LTL and changes in plaque volume over 6 years, either in the total sample or when stratified by sex. Likewise, no significant associations were found between LTL changes and the odds of SA progression over a 6-year period. Similar results were found when considering short telomere load changes. These findings suggest limited utility of LTL dynamics as an early biomarker for SA progression in healthy middle-aged individuals.
eng
PESA cohort
Prospective study
Subclinical atherosclerosis progression
Telomere length dynamics
Telomere length dynamics do not predict subclinical atherosclerosis progression over a six-year period.
research article
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Telomere length dynamics_Geroscience_2026.pdf