2026-10-05T04:01:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/277142026-09-16T00:17:12Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Pena-Couso, Laura
author
Sicilia, Jon
author
Vieto, Sofía
author
Silva-Rojas, Roberto
author
Sánchez-Díaz, María
author
Calvo, Enrique
author
Romero-Becerra, Rafael
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Folgueira, Cintia
author
Herrera-Melle, Leticia
author
Justo-Méndez, Raquel
author
Hong, Xiaotong
author
Campanario, Silvia
author
López, Juan A
author
Crainiciuc, Georgiana
author
Gil, María
author
Martín-Salamanca, Sandra
author
Lukesova, Vera
author
Segalés, Jessica
author
Serrano, Antonio L
author
Ballesteros, Iván
author
León, Marta
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de Andrés-Laguillo, Macarena
author
Stifter, Sebastian A
author
Esteban-Martínez, Lorena
author
Isern, Joan
author
Alegre-Cebollada, Jorge
author
Torres, Miguel
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Greter, Melanie
author
Vázquez, Jesús
author
Enríquez, José A
author
Sabio-Buzo, Guadalupe
author
Muñoz-Cánoves, Pura
author
Hidalgo, Andrés
author
Nicolás-Ávila, José A
2026-09-15T09:50:42Z
2026-09-15T09:50:42Z
2026-09-04
Sci Immunol. 2026 Sep 4;11(123):eaeb9244.
SCIENCE IMMUNOLOGY
42696609
https://hdl.handle.net/20.500.12105/27714
Removal of cellular waste from the extracellular space is fundamental for tissue health. Because the rate of material ejected by parenchymal cells varies across tissues, we searched for mechanisms that couple waste production and removal. Here, we show that the uptake of parenchyma-released mitochondria by macrophages is prominent across organs that rely on oxidative respiration-including heart, skeletal muscle, and brown adipose tissue-and that macrophage numbers closely align with the mitochondrial activity of each of these organs. We found that the mitochondrial activity of myofibers dictates the abundance of macrophages by modulating colony-stimulating factor 1 (CSF1) availability and the number of CSF1-producing fibroblasts in the tissue. Consequently, inhibition of CSF1-CSF1 receptor (CSF1R) signaling depleted macrophages and collapsed the mitochondrial activity of skeletal muscles. We propose that, by coupling macrophage abundance to the mitochondrial activity of their parenchyma, tissues ensure efficient waste disposal and fitness.
eng
Tissue mitochondrial activity dictates the macrophage pool size.
research article
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Tissue mitochondrial activity_Sci Immunol_2026.pdf