2026-10-05T04:01:32Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/277142026-09-16T00:17:12Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc Pena-Couso, Laura author Sicilia, Jon author Vieto, Sofía author Silva-Rojas, Roberto author Sánchez-Díaz, María author Calvo, Enrique author Romero-Becerra, Rafael author Folgueira, Cintia author Herrera-Melle, Leticia author Justo-Méndez, Raquel author Hong, Xiaotong author Campanario, Silvia author López, Juan A author Crainiciuc, Georgiana author Gil, María author Martín-Salamanca, Sandra author Lukesova, Vera author Segalés, Jessica author Serrano, Antonio L author Ballesteros, Iván author León, Marta author de Andrés-Laguillo, Macarena author Stifter, Sebastian A author Esteban-Martínez, Lorena author Isern, Joan author Alegre-Cebollada, Jorge author Torres, Miguel author Greter, Melanie author Vázquez, Jesús author Enríquez, José A author Sabio-Buzo, Guadalupe author Muñoz-Cánoves, Pura author Hidalgo, Andrés author Nicolás-Ávila, José A author 2026-09-04 Removal of cellular waste from the extracellular space is fundamental for tissue health. Because the rate of material ejected by parenchymal cells varies across tissues, we searched for mechanisms that couple waste production and removal. Here, we show that the uptake of parenchyma-released mitochondria by macrophages is prominent across organs that rely on oxidative respiration-including heart, skeletal muscle, and brown adipose tissue-and that macrophage numbers closely align with the mitochondrial activity of each of these organs. We found that the mitochondrial activity of myofibers dictates the abundance of macrophages by modulating colony-stimulating factor 1 (CSF1) availability and the number of CSF1-producing fibroblasts in the tissue. Consequently, inhibition of CSF1-CSF1 receptor (CSF1R) signaling depleted macrophages and collapsed the mitochondrial activity of skeletal muscles. We propose that, by coupling macrophage abundance to the mitochondrial activity of their parenchyma, tissues ensure efficient waste disposal and fitness. Sci Immunol. 2026 Sep 4;11(123):eaeb9244. SCIENCE IMMUNOLOGY 42696609 https://hdl.handle.net/20.500.12105/27714 Tissue mitochondrial activity dictates the macrophage pool size.