2026-10-08T10:31:32Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/276902026-09-08T00:15:49Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud author Iniesta, Carlos author Hernando Sebastian, Victoria author Jarrin Vera, Inmaculada author Pérez de la Cámara, Santiago author De la Torre-Lima, Javier author Villanueva, Vicent author Mayorga, Mª Isabel author Belda, Josefina author Soteras, Maribel author Torres Lana, Álvaro author Echeverria, Aitziber author Monteagudo-Piqueras, Olga author Marcos, Henar author Ben Cheikh, Wafa author Portocarrero-Núñez, Julián-Alexander author Álvarez-Del Arco, Débora author Diaz Franco, Asuncion author Del Amo, Julia author SIPrEP 2026-09-07T15:15:24Z 2026-09-07T15:15:24Z 2025-10 Iniesta C, Hernando V, Jarrín I, Pérez de la Cámara S, De la Torre-Lima J, Villanueva V, Mayorga MI, Belda J, Soteras M, Torres Lana Á, Echeverria A, Monteagudo-Piqueras O, Marcos H, Ben Cheikh W, Portocarrero-Núñez JA, Álvarez-Del Arco D, Diaz A, Del Amo J; SIPrEP. SIPrEP: A tool to monitor HIV pre-exposure prophylaxis in Spain. Enferm Infecc Microbiol Clin (Engl Ed). 2025 Oct;43(8):515-522. doi: 10.1016/j.eimce.2025.06.012. PMID: 41043889. 10.1016/j.eimce.2025.06.012 Enfermedades infecciosas y microbiologia clinica (English ed.) https://hdl.handle.net/20.500.12105/27690 Objectives: Pre-exposure prophylaxis (PrEP) has been available in Spain since November 2019 and implemented nationally in 2021. Monitoring the implementation process is essential to optimize the strategy. This manuscript describes the Spanish PrEP Programme Information System (SIPrEP), its methodology, and characteristics of PrEP users from November 2019 to May 2024. Methods: Nationwide open cohort that collects data on persons ≥16 years who were prescribed PrEP in Spain. The study included participants with public program PrEP prescriptions since November 1, 2019. The project was piloted and fully implemented in July 2020. Results: By May 2024, 28,798 people received public program PrEP in Spain, and 4159 users were included in SIPrEP. Most were men (99%, n=4117), primarily gay, bisexual, and other men who have sex with men (GBMSM) (97%, n=4005), with a median age of 36 years (IQR: 30-43). Most were born in Spain (74%, n=3075), and 36% (n=1503) had university education. Referrals came from STI centers (19%, n=805) and primary care (20%, n=820). At entry, 8% (n=348) had syphilis, 7% chlamydia (n=270) and 7% (n=300) had gonococcal infection. Among users, 15% (n=642) discontinued PrEP, and 34% (n=216) of them restarted later. There were four HIV seroconversions (incidence 0.12/100 person-years [95% CI: 0.05-0.33]). Conclusions: SIPrEP provides valuable real-world data for optimizing interventions but requires improved national coverage. eng HIV PrEP Prevención Prevention Public health Salud pública Salud sexual Sexual health VIH SIPrEP: A tool to monitor HIV pre-exposure prophylaxis in Spain. research article QWNlcHRhbmRvIGVzdGEgbGljZW5jaWEsIFVzdGVkIChlbCBhdXRvci9lcyBvIGVsIHByb3BpZXRhcmlvL3MgZGUgbG9zIGRlcmVjaG9zIGRlIGF1dG9yKSBjb25jZWRlIGEgUkVQSVNBTFVEIGVsIGRlcmVjaG8gbm8gZXhjbHVzaXZvIGRlIHJlcHJvZHVjaXIsIGNvbnZlcnRpciwgeS9vIGRpc3RyaWJ1aXIgc3UgZG9jdW1lbnRvIChpbmNsdXllbmRvIHN1IHJlc3VtZW4pIGEgbml2ZWwgbXVuZGlhbCBlbiBmb3JtYXRvIGRpZ2l0YWwsIGluY2x1eWVuZG8sIGF1ZGlvIHkgdsOtZGVvLCBhIHRyYXbDqXMgZGUgc3UgcmVwb3NpdG9yaW8gaW5zdGl0dWNpb25hbC4KClVzdGVkIGFjZXB0YSBxdWUgUkVQSVNBTFVEIHB1ZWRlLCBzaW4gYWx0ZXJhciBzdSBjb250ZW5pZG8sIGNvbnZlcnRpciBzdSBkb2N1bWVudG8gYSBjdWFscXVpZXIgb3RybyBmb3JtYXRvIGRpZ2l0YWwgZGUgZGF0b3MsIGF1ZGlvIHkgdmlkZW8sIGNvbiBlbCBwcm9ww7NzaXRvIGRlIHF1ZSBwdWVkYSBzZXIgYWxvamFkbyBlbiBlbCByZXBvc2l0b3Jpby4KClVzdGVkIGVzdMOhIGRlIGFjdWVyZG8gY29uIHF1ZSBSRVBJU0FMVUQgcHVlZGEgY29uc2VydmFyIG3DoXMgZGUgdW5hIGNvcGlhIGRlIGVzdGUgZG9jdW1lbnRvIHBhcmEgYXNlZ3VyYXIgc3Ugc2VndXJpZGFkLCBwcmVzZXJ2YWNpw7NuIHkgYWNjZXNvLgoKVXN0ZWQgZGVjbGFyYSBxdWUgZWwgZG9jdW1lbnRvIGVzIHVuIHRyYWJham8gb3JpZ2luYWwsIHkgcXVlIHRpZW5lIGVsIGRlcmVjaG8gZGUgb3RvcmdhciBsb3MgZGVyZWNob3MgY29udGVuaWRvcyBlbiBlc3RhIGxpY2VuY2lhLiBUYW1iacOpbiBkZWNsYXJhIHF1ZSBzdSBwZXRpY2nDs24gbm8gaW5mcmluZ2UgbG9zIGRlcmVjaG9zIGRlIGF1dG9yIGRlIG5hZGllLgoKU2kgZWwgZG9jdW1lbnRvIGNvbnRpZW5lIG1hdGVyaWFsZXMgcGFyYSBsb3MgcXVlIG5vIHNlIHRpZW5lbiBsb3MgZGVyZWNob3MgZGUgYXV0b3IsIHVzdGVkIGRlY2xhcmEgcXVlIGhhIG9idGVuaWRvIGVsIHBlcm1pc28gc2luIHJlc3RyaWNjacOzbiBkZWwgcHJvcGlldGFyaW8gZGUgbG9zIGRlcmVjaG9zIHkgcXVlIGVuIGRpY2hvIG1hdGVyaWFsLCBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkYSB5IHJlY29ub2NpZGEgc3UgYXV0b3LDrWEgZGVudHJvIGVsIHRleHRvIG8gZGVsIGNvbnRlbmlkbyBkZSBkaWNobyBkb2N1bWVudG8uCgpTaSBlbCBlbnbDrW8gc2UgYmFzYSBlbiB1biB0cmFiYWpvIHF1ZSBoYSBzaWRvIHBhdHJvY2luYWRvIG8gYXBveWFkbyBwb3IgdW5hIGFnZW5jaWEgdSBvcmdhbml6YWNpw7NuIGRpc3RpbnRhIGEgUkVQSVNBTFVELCB1c3RlZCBhY2VwdGEgcXVlIGhhIGN1bXBsaWRvIGNvbiBlbCBkZXJlY2hvIGRlIHJldmlzacOzbiB5IG90cmFzIG9ibGlnYWNpb25lcyByZXF1ZXJpZGFzIHBvciBjb250cmF0byBvIGFjdWVyZG8uCgpSRVBJU0FMVUQgaWRlbnRpZmljYXLDoSBjbGFyYW1lbnRlIHN1KHMpIG5vbWJyZShzKSBjb21vIGF1dG9yKHMpIG8gcHJvcGlldGFyaW8ocykgZGVsIGRvY3VtZW50bywgeSBubyBoYXLDoSBuaW5ndW5hIGFsdGVyYWNpw7NuLCBleGNlcHRvIHNlZ8O6biBsbyBwZXJtaXRpZG8gcG9yIGVzdGEgbGljZW5jaWEuCg== URL https://repisalud.isciii.es/bitstreams/5339394b-eaa1-4eac-bb56-a655d1979d2a/download File MD5 effbd2553f971ce1fe701ab03510ab66 741260 application/pdf SIPrEPToolMonitorHIV_2025.pdf