2026-09-02T00:46:33Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/276832026-08-22T00:15:36Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610
Repisalud
author
Peinado, Francisco M
author
Pérez-Cantero, Ainhoa
author
Olivas-Martínez, Alicia
author
Espín-Moreno, Lydia
author
de Haro, Tomás
author
Boada, Luis D
author
Rodríguez-Carrillo, Andrea
author
Govarts, Eva
author
Pedraza-Díaz, Susana
author
Esteban-Lopez, Marta
author
Blaha, Ludek
author
Blahova, Lucie
author
Janasik, Beata
author
Wasowicz, Wojciech
author
Lignell, Sanna
author
Rambaud, Loïc
author
Riou, Margaux
author
Fillol, Clémence
author
Denys, Sébastien
author
Murawski, Aline
author
Brantsæter, Anne Lise
author
Sakhi, Amrit Kaur
author
Iszatt, Nina
author
Schoeters, Greet
author
Kolossa-Gehring, Marike
author
Fernández, Mariana F
author
Mustieles, Vicente
funder
Unión Europea. Comisión Europea. H2020
funder
Ministerio de Agricultura, Pesca y Alimentación (España)
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
funder
The Research Council of Norway
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación Ramón Areces
funder
Unión Europea. Fondo Social Europeo (ESF/FSE)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Swedish Environmental Protection Agency
funder
Swedish Civil Contingencies Agency
funder
Swedish National Food Agency
funder
Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (Deutschland)
funder
Federal Ministry of Education and Research (Deutschland)
funder
Norwegian Institute of Public Health
2026-08-21T12:11:38Z
2026-08-21T12:11:38Z
2025-09-01
Peinado FM, Pérez-Cantero A, Olivas-Martínez A, Espín-Moreno L, de Haro T, Boada LD, Rodríguez-Carrillo A, Govarts E, Pedraza-Díaz S, Esteban-López M, Blaha L, Blahova L, Janasik B, Wasowicz W, Lignell S, Rambaud L, Riou M, Fillol C, Denys S, Murawski A, Brantsæter AL, Sakhi AK, Iszatt N, Schoeters G, Kolossa-Gehring M, Fernández MF, Mustieles V. Adolescent exposure to benzophenone ultraviolet filters: cross-sectional associations with obesity, cardiometabolic biomarkers, and asthma/allergy in six European biomonitoring studies. Environ Res. 2025 Sep 1;280:121912. doi: 10.1016/j.envres.2025.121912. Epub 2025 May 21. PMID: 40409449.
10.1016/j.envres.2025.121912
Environmental Research
40409449
https://hdl.handle.net/20.500.12105/27683
Background: Exposure to benzophenone-1 (BP-1) and benzophenone-3 (BP-3), widely used as UV filters in personal care products, has been associated with adverse health effects. However, epidemiological evidence is limited and inconclusive, particularly in vulnerable populations such as teenagers. Objective: To examine the relation between BP-1 and BP-3 concentrations and obesity, cardiometabolic biomarkers, and asthma/allergy outcomes in European teenagers, including possible sex-specific associations. Methods: A multi-country cross-sectional study was conducted using pooled data from six aligned studies from the Human Biomonitoring for Europe Initiative (HBM4EU). Sociodemographic data, cardiometabolic biomarkers, and asthma/allergy outcomes were collected through questionnaires. Anthropometric data and BMI z-scores were calculated (n = 1339). Plasma/serum cardiometabolic biomarkers and asthma/allergy outcomes were available for a subsample (n = 173-594). Urinary BP-1 and BP-3 concentrations were adjusted for creatinine dilution using the traditional standardization (trad.) and the covariate-adjusted creatinine standardization (CAS) method. Generalized additive models, linear, logistic, and multinomial mixed models were applied, and sex-interaction terms were tested. Results: Each natural log-unit increase in urinary BP-3 (CAS) concentrations was associated with higher odds of obesity in the whole population (OR: 1.20; 95%CI: 1.04-1.38). Sex-specific associations were also found with BP-1 (CAS) and BP-3 (CAS) concentrations, which were associated with higher odds of obesity in male teenagers (OR: 1.25; 95% CI: 1.01-1.55; OR: 1.34; 95%CI: 1.09-1.65, respectively). Linear mixed models showed consistent findings toward higher BMI z-scores. A negative association was found between BP-1 (CAS) concentration and serum adiponectin levels in females (% change per loge-unit increase: -3.73, 95%CI: -7.32, -0.10). BP-3 (CAS) concentrations were also associated with higher odds of non-food allergies in males (OR: 1.27; 95%CI: 1.00-1.63). Traditional creatinine adjustment showed similar or slightly attenuated estimates compared to the CAS method. Conclusions: BP-1 and BP-3 exposure was cross-sectionally associated with higher odds of obesity in European male teenagers, highlighting the need to update regulations and keep exposure levels as low as practically achievable. Longitudinal studies are needed to confirm these findings.
eng
Allergy
Benzophenone
Endocrine disruption
HBM4EU
Obesity
PARC
UV filter
Adolescent exposure to benzophenone ultraviolet filters: cross-sectional associations with obesity, cardiometabolic biomarkers, and asthma/allergy in six European biomonitoring studies.
research article
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