2026-07-25T03:51:31Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/275912026-07-16T00:16:34Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Herrera-Melle, Leticia author Cicuéndez, Beatriz author López, Juan Antonio author Dumesic, Phillip A author Wilensky, Sarah E author Rodríguez, Elena author Leiva-Vega, Luis author Caballero, Ainoa author León, Marta author Vázquez, Jesús author Spiegelman, Bruce M author Folgueira, Cintia author Mora, Alfonso author Sabio, Guadalupe author 2024-11 Skeletal muscle, with its remarkable plasticity and dynamic adaptation, serves as a cornerstone of locomotion and metabolic homeostasis in the human body. Muscle tissue, with its extraordinary capacity for force generation and energy expenditure, plays a fundamental role in the movement, metabolism, and overall health. In this context, we sought to determine the role of p38α in mitochondrial metabolism since mitochondrial dynamics play a crucial role in the development of muscle-related diseases that result in muscle weakness. We conducted our study using male mice (MCK-cre, p38α and PGC1α ) and mouse primary myoblasts. We analyzed mitochondrial metabolic, physiological parameters as well as proteomics, western blot, RNA-seq analysis from muscle samples. Our findings highlight the critical involvement of muscle p38α in the regulation of mitochondrial function, a key determinant of muscle strength. The absence of p38α triggers changes in mitochondrial dynamics through the activation of PGC1α, a central regulator of mitochondrial biogenesis. These results have substantial implications for understanding the complex interplay between p38α kinase, PGC1α activation, and mitochondrial content, thereby enhancing our knowledge in the control of muscle biology. This knowledge holds relevance for conditions associated with muscle weakness, where disruptions in these molecular pathways are frequently implicated in diminishing physical strength. Our research underscores the potential importance of targeting the p38α and PGC1α pathways within muscle, offering promising avenues for the advancement of innovative treatments. Such interventions hold the potential to improve the quality of life for individuals affected by muscle-related diseases. Acta Physiol (Oxf). 2024 Nov;240(11):e14234. ACTA PHYSIOLOGICA 39361268 https://hdl.handle.net/20.500.12105/27591 mitochondrial biogenesis mitochondrial dynamics muscle strength p38α skeletal muscle p38α kinase governs muscle strength through PGC1α in mice.