2026-07-06T08:10:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/275752026-06-30T00:17:41Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Sánchez-Mora, Patricia
author
Habela, Miguel A
author
Del Peso, Teresa
author
Grande Ávila, Ana Candela
author
García López, Ana María
author
Mata García Soldado, Jennifer
author
Tapia, María M
author
Molero-Sanz, Francisca
author
Herrero-Romero, Laura
author
Olmeda, A Sonia
author
Valcárcel, Félix
author
Estrada-Peña, Agustín
author
Negredo, Anabel
author
Sánchez-Seco, María Paz
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
Unión Europea. Comisión Europea. NextGenerationEU
2026-06-29T12:17:16Z
2026-06-29T12:17:16Z
2026-04-01
Sánchez-Mora P, Habela MA, del Peso T, Grande Ávila AC, García López AM, Mata García Soldado J, Tapia MM, Molero F, Herrero L, Olmeda AS, Valcárcel F, Estrada-Peña A, Negredo A and Sánchez-Seco MP (2026) Detection and genetic characterization of Crimean-Congo hemorrhagic fever virus in ticks from western Spain (2017, 2020-2024). Front. Vet. Sci. 13:1789622. doi: 10.3389/fvets.2026.1789622
10.3389/fvets.2026.1789622
Frontiers in Veterinary Science
41994259
https://hdl.handle.net/20.500.12105/27575
Introduction: Crimean-Congo hemorrhagic fever virus (CCHFV) was first detected in Spain in ticks collected from red deer in southwestern Cáceres. Since then, this region, established as endemic, has been the focus of several surveillance studies. However, updated data on viral circulation in this area remain limited. Materials and methods: We conducted a retrospective surveillance study to assess the presence and genetic diversity of CCHFV in ticks collected in central and southern Cáceres over multiple years (2017 and 2020-2024). A total of 3,183 ticks, grouped into 1,569 pools, were collected from wild ungulates, livestock, domestic animals and vegetation, and analyzed by two PCR methods. Positive pools were characterized by Sanger sequencing. Results: CCHFV was exclusively detected in Hyalomma lusitanicum ticks, with an overall infection rate of 1.54% (95% CI: 1.14-2.03). Most positive pools originated from wild ungulates, particularly red deer. Genetic analysis revealed the circulation of two CCHFV genotypes, predominantly genotype III. Discussion: The detection of CCHFV in ticks collected over multiple years supports the sustained circulation of the virus in southwestern Cáceres. Our findings also reinforce the key role of H. lusitanicum as the main vector maintaining the virus in wild ungulates and underscore the genetic diversity of circulating strains and the importance of using multiple molecular methods. These results emphasize the need for continuous surveillance in endemic areas to monitor viral circulation and assess animal and public health risks.
eng
Crimean-Congo hemorrhagic fever virus
Hyalomma lusitanicum
Spain
Genetic diversity
Surveillance
Viral circulation
Wild ungulates
Detection and genetic characterization of Crimean-Congo hemorrhagic fever virus in ticks from western Spain (2017, 2020-2024).
research article
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