2026-07-06T08:18:14Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/275702026-06-30T09:10:31Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Sánchez-Mora, Patricia
author
Molero-Sanz, Francisca
author
Navascués, Ana
author
Zurita, Nelly Daniela
author
Zamarrón, Pilar
author
Lagarejos, Eduardo
author
Gómez, Sara
author
Cardona, Pere Joan
author
Carrasco, Blanca
author
López-Lomba, Marta
author
Escribano, Isabel
author
Martínez-Expósito, Óscar
author
Del Peso, Teresa
author
Herrero-Romero, Laura
author
Negredo, Anabel
author
Guillén-Calvo, Laura
author
Peña Gallego, Ana
author
Gutiérrez-López, Rafael
author
Labiod, Nuria
author
Vazquez, Ana
author
Sánchez-Seco, María Paz
author
Gutiérrez-López, Rafael
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
2026-06-29T09:49:37Z
2026-06-29T09:49:37Z
2026
Sánchez-Mora P, Molero F, Navascués A, Zurita ND, Zamarrón P, Lagarejos E, Gómez S, Cardona PJ, Carrasco B, López-Lomba M, Escribano I, Martínez-Expósito Ó, Del Peso T, Herrero L, Negredo A, Guillén-Calvo L, Peña A, Gutiérrez-López R, Labiod N, Vázquez A, Sánchez-Seco MP. Molecular epidemiology and surveillance of imported dengue in travellers returning to Spain, 2022-2024. Travel Med Infect Dis. 2026 May-Jun;71:102986. doi: 10.1016/j.tmaid.2026.102986. Epub 2026 May 4. PMID: 42092667.
10.1016/j.tmaid.2026.102986
Travel Medicine and Infectious Disease
42092667
https://hdl.handle.net/20.500.12105/27570
Introduction: Dengue is the most significant vector-borne viral disease in global morbidity and mortality, and it is considered a re-emerging disease spreading into new regions. The risk of autochthonous dengue virus transmission in Spain remains high due to the increasing number of travellers returning from endemic areas and the presence of Aedes albopictus within our territory. Conducting epidemiological and molecular studies on returning travellers from endemic areas may be crucial to discern transmission patterns and track the global spread of the virus. This study focuses on the molecular characterization of suspected imported dengue cases from 2022 to 2024. Methods: We analysed 600 samples from 539 suspected dengue-infected travellers between 2022 and 2024. All samples were tested by a quantitative RT-PCR, and PCR-positive cases were confirmed by performing a non-overlapping nested RT-PCR, going under subsequent sequencing to identify viral diversity. Results: Of the 539 suspected cases, 183 were confirmed as DENV-positive, with Cuba as the most common travel origin associated with infections. Molecular analysis of positive samples identified all four DENV serotypes and ten genotype groups, with DENV-3 genotype III as the most predominant. Additionally, among confirmed cases reported from regions with Aedes albopictus presence, 73% (94/129) occurred during the vector's active season (May-November), increasing the risk of local transmission. Conclusion: Our results highlight the importance of returning travellers as sentinels for ongoing dengue outbreaks and epidemiology in endemic regions. Additionally, these emphasize the importance of early case identification through sentinel surveillance to prevent potential autochthonous transmission.
eng
Aedes albopictus
Dengue virus
Imported cases
Molecular surveillance
Serotype
Spain
Travellers
Molecular epidemiology and surveillance of imported dengue in travellers returning to Spain, 2022-2024.
research article
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MolecularEpidemiologySurveillanceImported_2026.pdf
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