2026-06-21T10:30:47Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/275272026-06-11T00:17:42Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Muñoz-Gómez, María José author Martin-Vicente, Maria author Vigil-Vazquez, Sara author Carrasco, Itziar author Lobo, Alicia Hernanz author Mas, Vicente author Vázquez, Mónica author Manzanares, Angela author Cano, Olga author Zamora, Clara author Alonso, Roberto author Sepulveda-Crespo, Daniel author Tarancon-Diez, Laura author Muñoz-Fernández, María Ángeles author Muñoz-Chapuli, Mar author Resino, Salvador author Navarro, Maria Luisa author Martinez, Isidoro author 2024-06 Purpose: We aimed to assess IgG antibodies against the SARS-CoV-2 spike protein (anti-SARS-CoV-2 S IgG) in vaccinated mothers and their infants at delivery and 2-3 months of age. Methods: We conducted a prospective study on mothers who received at least one dose of the COVID-19 vaccine (Pfizer-BNT162b2, Moderna mRNA-1273, or Oxford-AstraZeneca ChAdOx1-S) during pregnancy and on their infants. The baseline was at the time of delivery (n = 93), and the end of follow-up was 2 to 3 months post-partum (n = 53). Serum anti-SARS-CoV-2 S IgG titers and ACE2 binding inhibition levels were quantified by immunoassays. Results: Mothers and infants had high anti-SARS-CoV-2 S IgG titers against the B.1 lineage at birth. However, while antibody titers were maintained at 2-3 months post-partum in mothers, they decreased significantly in infants (p < 0.001). Positive and significant correlations were found between anti-SARS-CoV-2 S IgG titers and ACE2-binding inhibition levels in mothers and infants at birth and 2-3 months post-partum (r > 0.8, p < 0.001). Anti-S antibodies were also quantified for the Omicron variant at 2-3 months post-partum. The antibody titers against Omicron were significantly lower in mothers and infants than those against B.1 (p < 0.001). Again, a positive correlation was observed for Omicron between IgG titers and ACE2-binding inhibition both in mothers (r = 0.818, p < 0.001) and infants (r = 0.386, p < 0.005). Previous SARS-CoV-2 infection and COVID-19 vaccination near delivery positively impacted anti-SARS-CoV-2 S IgG levels. Conclusions: COVID-19 mRNA vaccines induce high anti-SARS-CoV-2 S titers in pregnant women, which can inhibit the binding of ACE2 to protein S and are efficiently transferred to the fetus. However, there was a rapid decrease in antibody levels at 2 to 3 months post-partum, particularly in infants. Muñoz-Gómez, M.J., Martin-Vicente, M., Vigil-Vazquez, S. et al. IgG antibody levels against the SARS-CoV-2 spike protein in mother–child dyads after COVID-19 vaccination. Infection 52, 813–824 (2024). https://doi.org/10.1007/s15010-023-02111-x 10.1007/s15010-023-02111-x Infection 37898587 https://hdl.handle.net/20.500.12105/27527 Antibody Infant Pregnant SARS-CoV-2 Spike glycoprotein Vaccine IgG antibody levels against the SARS-CoV-2 spike protein in mother-child dyads after COVID-19 vaccination.