2026-06-19T22:41:21Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/275242026-06-10T08:02:56Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Martín-Carbonero, Luz author Gutierrez, Ángela author Bisbal, Otilia author Vergas, Jorge author González-Baeza, Alicia author Rodríguez Martín, Carmen author Vivancos, María Jesús author Sanz, José author Álvarez, Beatriz author Palomar, Marina author de Los Santos, Ignacio author Sepulveda-Crespo, Daniel author Resino, Salvador author Berenguer, Juan author Cano-Smith, Joanna author González-García, Juan author Ryan, Pablo author 2024-10 Introduction: We analyzed epidemiological, clinical characteristics, and the response to treatment in people living with HIV (PLHIV) who recently acquired hepatitis C (RAHC) in a multicentre study in Madrid (Spain). Methods: Multicenter, ambispective, observational study of RAHC in men who have sex with men (MSM) infected with HIV. Clinical, epidemiological, and RAHC evolution were recorded prospectively in 2019 and 2020 and retrospectively in 2017 and 2018. In patients who received HCV treatment, sustained virological response (SVR) was provided 12 weeks after the end of treatment in an intention to treat analysis (ITT): all treated patients were included; and in analysis per-protocol (PP): missing patients were excluded. Results: Overall, 133 patients were included. Median (IQR) age was 40 (34.3-46.1) years, 90.9% had at least one previous sexual transmission disease (STD), and 33.6% had previously hepatitis C. More than half of the prospective sample included patients using chemsex related drugs (57.3%), 45.7% of them intravenously. The most prevalent genotype was G1a (66.2%), followed by G4 (11.3%). Ten of 90 patients evaluated for spontaneous cure (11%) cured the infection spontaneously, and 119 had treatment after a median time of 1.8 (0.7-4.6) months: sustained virological response (SVR) was achieved in 90.7% in the ITT and 94.7% in the PP analysis, with no differences regarding the direct-acting antiviral agents (DAA) combination used. Conclusions: MSM infected by HIV with a RAHC were exposed to high-risk sexual behavior. Spontaneous cure rate was low, while SVR after treatment was achieved by more than 90%. Martín-Carbonero L, Gutierrez Á, Bisbal O, Vergas J, González-Baeza A, Rodríguez Martín C, Vivancos MJ, Sanz J, Álvarez B, Palomar M, de Los Santos I, Sepúlveda-Crespo D, Resino S, Berenguer J, Cano-Smith J, González-García J, Ryan P. Recently acquired hepatitis C: Epidemiological characteristics and treatment response in a large cohort of MSM living with HIV in Madrid. Enferm Infecc Microbiol Clin (Engl Ed). 2024 Oct;42(8):414-419. doi: 10.1016/j.eimce.2023.06.011. Epub 2023 Nov 7. PMID: 37945463. 10.1016/j.eimce.2023.06.011 Enfermedades infecciosas y microbiologia clinica (English ed.) 37945463 https://hdl.handle.net/20.500.12105/27524 HCV HIV Hepatitis C de reciente adquisición Hombres que tienen sexo con hombres MSM Recently acquired hepatitis C VIH Virus hepatitis C Recently acquired hepatitis C: Epidemiological characteristics and treatment response in a large cohort of MSM living with HIV in Madrid.