2026-07-25T03:57:35Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/275002026-06-05T00:22:21Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc d'Entremont, Marc-André author Poorthuis, Michiel H F author Fiolet, Aernoud T L author Amarenco, Pierre author Boczar, Kevin Emery author Buysschaert, Ian author Chan, Noel C author Cornel, Jan H author Jannink, Jalina author Jansen, Shirley author Kedev, Sasko author Keech, Anthony C author Layland, Jamie author Mewton, Nathan author Montalescot, Gilles author Pascual-Figal, Domingo A author Rodriguez, Alfredo E author Shah, Binita author Teraa, Martin author van Zelm, Aimee author Wang, Yongjun author Mosterd, Arend author Kelly, Peter author Eikelboom, John author Jolly, Sanjit S author 2025-07-07 Randomized trials of colchicine in secondary prevention of atherosclerotic cardiovascular disease have shown mixed results. A systematic review and study-level meta-analysis of randomized controlled trials was performed comparing colchicine vs no colchicine in a secondary-prevention atherosclerotic cardiovascular disease population. A fixed-effect inverse variance model was applied using the intention-to-treat population from the included trials. The primary outcome was the composite of cardiovascular death, myocardial infarction, or stroke. Nine trials, including 30 659 patients (colchicine 15 255, no colchicine 15 404) with known coronary artery disease or stroke, were included. Compared with no colchicine, patients randomized to colchicine had a relative risk (RR) of 0.88 [95% confidence interval (CI) 0.81-0.95, P = .002] for the primary composite outcome, including a RR of 0.94 for cardiovascular death (95% CI 0.78-1.13, P = .5), a RR of 0.84 for myocardial infarction (95% CI 0.73-0.97, P = .016), and a RR of 0.90 for stroke (95% CI 0.80-1.02, P = .09). Colchicine was associated with a RR of 1.35 for hospitalization for gastrointestinal events (95% CI 1.10-1.66, P = .004) with no increase in hospitalization for pneumonia, newly diagnosed cancers, or non-cardiovascular death. In patients with prior coronary disease or stroke, colchicine reduced the composite of cardiovascular death, myocardial infarction, or stroke by 12%. Eur Heart J. 2025 Jul 7;46(26):2564-2575 EUROPEAN HEART JOURNAL 40314334 https://hdl.handle.net/20.500.12105/27500 Colchicine Coronary revascularization Inflammation Myocardial infarction Stroke Colchicine for secondary prevention of vascular events: a meta-analysis of trials.