2026-05-17T00:18:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/274572026-05-09T00:18:39Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_25179
Repisalud
author
Navarro-Lleó, Noemi
author
Aznar-Córdoba, Silvia
author
Asensio-Cob, Dunia
author
Luque, Daniel
author
Rodríguez, Javier M
author
Gozalbo-Rovira, Roberto
author
Alcaraz-Soriano, María Jesús
author
Cárcamo-Calvo, Roberto
author
Rodríguez-Díaz, Jesús
author
Buesa, Javier
funder
Instituto de Salud Carlos III
funder
Generalitat Valenciana (España)
2026-05-08T20:48:05Z
2026-05-08T20:48:05Z
2025-08
Navarro-Lleó N, Aznar-Córdoba S, Asensio-Cob D, Luque D, Rodríguez JM, Gozalbo-Rovira R, Alcaraz-Soriano MJ, Cárcamo-Calvo R, Rodríguez-Díaz J, Buesa J. Seroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain. J Med Virol. 2025 Aug;97(8):e70542. doi: 10.1002/jmv.70542. PMID: 40751697; PMCID: PMC12317683.
10.1002/jmv.70542
Journal of Medical Virology
40751697
https://hdl.handle.net/20.500.12105/27457
Species A rotavirus (RVA) is a major cause of acute gastroenteritis in children. However, three other rotavirus species (RVB, RVC, and RVH) are also able to infect humans. It has been suggested that vaccination against RVA could facilitate an increase of non-A rotavirus infections. We investigated the antibody prevalence against RVA, RVB, RVC, and RVH in 420 human sera collected between 2020 and 2022 from different age groups in Valencia (Spain). Antibody prevalence rates to RVA, RVB, RVC, and RVH were 79.3%, 17.9%, 18.8%, and 14.5%, respectively. Antibody titers against RVA remained consistent across the different age groups, and RVB showed low titers except in younger individuals. RVC-specific antibodies peaked in children 5-10 years of age, whereas RVH exhibited the highest titers in the elderly. The detection of antibodies against non-A rotaviruses in humans in Spain, for the first time against RVB and RVH, highlights the need for their surveillance.
eng
VP2
VP6
Antibodies
Non‐A rotaviruses
Seroepidemiology
Seroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain.
research article
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SeroepidemiologyHumanNonSpeciesRotavirus_2025.pdf
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Supplementary_SeroepidemiologyHumanNonSpeciesRotavirus_2025.zip