2026-04-27T03:34:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/274402026-04-21T00:17:27Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Galindo-Moreno, Pablo
author
Gutierrez-Garrido, Lourdes
author
Duarte, Juan
author
Robles-Vera, Iñaki
author
Martin-Morales, Natividad
author
O'Valle, Francisco
author
Olaechea, Allinson
author
Carrillo-Galvez, Ana Belén
author
Padial-Molina, Miguel
2026-04-20T11:49:25Z
2026-04-20T11:49:25Z
2025-07
Clin Oral Implants Res. 2025 Jul;36(7):802-820.
https://hdl.handle.net/20.500.12105/27440
40062725
Clinical Oral Implants Research
To analyze the clinical, radiographic, and microbiological changes around implants with a multiphosphonate-treated surface, prosthetically loaded with two different protocols after 5 years of functional loading. A randomized clinical trial was designed to initiate prosthetic loading over single dental implants after 8 (control) or 4 weeks (test). Several variables were analyzed, including patients' level variables, intrasulcular biofilm, and marginal bone level at several time points, from 1 to 60 months after loading. A total of 23 patients attended the 5-year follow-up visit. No clinical variable changed over time, except mucosal thickness from dental impressions to prosthesis delivery. No significant radiographic differences were observed either over time or between groups. Microbiologically, there was a change in the microbiome from the constitution of the biological width to the final follow-up. Seven species changed significantly, with a significant increase in Porphyromonas gingivalis and Tannerella forsythia from 12 to 60 months and a decrease in the other species. However, changes in the relative abundance of species over time, whether increasing or decreasing, did not show a correlation with marginal bone loss. Implants with a multiphosphonate-treated surface showed no differences in clinical and radiographic variables after 5 years of function, regardless of the prosthetic loading protocol used. From a microbiological point of view, although there was an evolution of the microbiome in the peri-implant sulcus towards Socransky's red circle pathogenic bacteria, no microorganism showed a significant correlation with the radiographic changes produced in the peri-implant bone over time.
eng
early loading
implant surface
marginal bone loss
microbiome
peri‐implantitis
Evolution in the Peri-Implant Oral Microbiome and Their Relationship to Long-Term Marginal Bone Loss: A Randomized Clinical Study.
research article
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Evolution in the Peri-Implant Oral Microbiome_Clin Oral Implants Res_2025.pdf