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oai:repisalud.isciii.es:20.500.12105/274372026-04-21T00:18:01Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Martínez-Gómez, Jesús author Ciprián, Giovana M author Le Coroller, Gwenaëlle author Pexaras, Achilleas author Fernández-Jiménez, Rodrigo author Appenzeller, Brice M R author Ruiz-Castell, Maria author 2025-11-10 Metabolic syndrome (MetS) and its components -central obesity, hypertriglyceridemia, reduced levels of serum high-density cholesterol (HDL-c), high blood pressure (BP), and hyperglycemia- are highly prevalent worldwide. Classical modifiable risk factors and environmental ones, such as exposure to pollutants can contribute to these high prevalence rates. We assessed whether exposure to pollutant mixtures was associated with MetS and its components, identifying key contributing pollutants. We analyzed data from 606 adults aged 25-64 from the European Health Examination Survey (2013-2015). Among 152 analyzed chemicals, 40 were present in over 50 % of the samples and classified as flame retardants, industrial wastes, and plastics (4), insecticides (17), herbicides (12), and fungicides (7). Using weighted quantile sum regressions, we estimated associations of groups of pollutants and the total mixture with metabolic outcomes. Exposure to insecticides was associated with high BP, hyperglycemia, and hypertriglyceridemia; herbicides with abdominal obesity; and fungicides with MetS, hyperglycemia, and hypertriglyceridemia. The total mixture increased the odds of all outcomes, except low HDL-c [average OR = 2.06 (5th PCT = 1.23); average OR = 1.83 (5th PCT = 1.03); average OR = 2.42 (5th PCT = 1.42); average OR = 1.19 (5th PCT = 0.77); average OR = 2.15 (5th PCT = 1.37); average OR = 1.89 (5th PCT = 1.10)]. Prosulfocarb was a probable contributor to the mixture effect on MetS and abdominal obesity, ClCFCA on hypertriglyceridemia, and PNP on high BP. In conclusion, chemical pollutants are more present in individuals with metabolic derangements, with potentially stronger effects when combined. Reducing pesticide use, promoting safer alternatives, and creating protocols/regulatory standards for multiple-exposure scenarios are crucial for public health. Sci Total Environ. 2025 Nov 10:1003:180691. https://hdl.handle.net/20.500.12105/27437 41075566 Science of the Total Environment Chemical mixtures Exposome Hair analysis Metabolic health Pesticides WQS regression Chemical pollutant mixtures associated with metabolic health: Results from the European Health Examination Survey in Luxembourg.