2026-06-14T10:37:33Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/273672026-03-27T01:18:33Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Virseda-Berdices, Ana
author
Requena, Belen
author
Berenguer, Juan
author
González-García, Juan
author
Gonzalez-Riano, Carolina
author
Díez, Cristina
author
Hontañon, Victor
author
Fernandez-Rodriguez, Amanda
author
Barbas, Coral
author
Resino, Salvador
author
Martín-Escolano, Rubén
author
Jimenez-Sousa, Maria Angeles
funder
Instituto de Salud Carlos III
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Comunidad de Madrid (España)
2026-03-26T11:42:42Z
2026-03-26T11:42:42Z
2026-01-12
Virseda-Berdices A, Requena B, Berenguer J, González-García J, Gonzalez-Riano C, Díez C, Hontañon V, Fernández-Rodríguez A, Barbas C, Resino S, Martín-Escolano R and Jiménez-Sousa MÁ (2026) Lipid and immune dysregulation and risk of metabolic disorders after HCV clearance in HIV/HCV-coinfected participants with cACLD: a retrospective study. Front. Immunol. 16:1674837. doi: 10.3389/fimmu.2025.1674837.
10.3389/fimmu.2025.1674837
Frontiers in Immunology
41601646
https://hdl.handle.net/20.500.12105/27367
Introduction: People with HIV and chronic hepatitis C may develop metabolic complications after sustained virologic response (SVR), possibly due to persistent molecular alterations induced by HCV. This study aimed to identify baseline (pre-treatment) lipid and immune biomarkers associated with post-SVR metabolic events in HIV/HCV-coinfected participants with compensated advanced chronic liver disease (cACLD) receiving long-term suppressive antiretroviral therapy. Methods: We conducted a retrospective study of 56 HIV/HCV-coinfected participants with cACLD. Untargeted lipidomic profiling was performed on baseline plasma samples using a liquid-chromatography-mass spectrometer. The outcome was the development of metabolic events (diabetes mellitus and/or hyperlipidemia) during follow-up, up to seven years post-HCV treatment. Statistical analyses included orthogonal partial least squares discriminant analysis (OPLS-DA), Cox regressions models, and Spearman correlations with inflammation-related biomarkers and immune checkpoint proteins, with multiple comparison corrections using the false discovery rate. Results: 25% participants developed metabolic events after SVR. OPLS-DA identified 163 lipid species (VIP scores≥1) associated with these events, and adjusted Cox regression confirmed significant associations for 24 of them. Lysophosphatidylcholines (LPCs) were the most prevalent, with higher baseline levels linked to increased metabolic risk. Participants who developed events also had higher levels of plasmalogens LPC (O-LPC), lysophosphatidylethanolamine (LPE), lysophosphatidylinositol (LPI), lysophosphatidic acid (LPA), and phosphosphatidylcholine (PC). Several lipid species correlated positively with the pro-inflammatory cytokine IL-18, the anti-inflammatory suppressor IL-1RA, and the immune checkpoint proteins IDO and S100A8/A9. Discussion: Pre-treatment lipid and immune dysregulation was associated with post-SVR metabolic events in HIV/HCV-coinfected participants, suggesting that HCV may leave a lasting metabolic imprint that contributes to adverse outcomes after viral clearance.
eng
HCV clearance
HIV/HCV-coinfection
Immunity
Lipidomic profile
Metabolic events
Lipid and immune dysregulation and risk of metabolic disorders after HCV clearance in HIV/HCV-coinfected participants with cACLD: a retrospective study.
research article
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