2026-06-14T03:52:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/273472026-03-24T01:17:40Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Pita-Martínez, Carlos
author
Jimenez-Sousa, Maria Angeles
author
Martinez-Picado, Javier
author
Rodríguez, Carmen Elena Gómez
author
Fariñas, Carmen
author
Galindo, Pepa
author
Roca-Oporto, Cristina
author
Santos, Jesús
author
Muñoz-García, Paula
author
Rava, Marta
author
Resino, Salvador
author
Martín-Escolano, Rubén
funder
Instituto de Salud Carlos III
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Comunidad de Madrid (España)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
2026-03-23T19:15:42Z
2026-03-23T19:15:42Z
2025-10-21
Pita-Martínez C, Jiménez-Sousa MÁ, Martinez-Picado J, Rodríguez CEG, Fariñas C, Galindo P, Roca-Oporto C, Santos J, Muñoz-García P, Rava M, Resino S and Martín-Escolano R (2025) Immune and senescence profiles associated with non-AIDS-defining cancer risk in people with HIV: a case-cohort study. Front. Immunol. 16:1707510. doi: 10.3389/fimmu.2025.1707510.
10.3389/fimmu.2025.1707510
Frontiers in Immunology
41194922
https://hdl.handle.net/20.500.12105/27347
Introduction: People with HIV (PWH) on effective antiretroviral therapy (ART) have an increased risk of developing Non-AIDS Defining Cancers (NADCs) compared to the general population, partly due to chronic inflammation and immune dysregulation. This study aimed to identify plasma biomarkers associated with the risk of developing NADCs in a cohort of PWH on ART. Methods: A case-cohort study was conducted within the Spanish CoRIS cohort, including 316 PWH on ART (71 cases and 245-individuals subcohort). Plasma levels of 24 immune regulation and senescence-associated secretory phenotype (SASP) biomarkers were quantified using Luminex technology. Cox proportional hazards regression models with Borgan II weights were used to assess the association between biomarker levels and the risk of NADC development (hazard ratios), adjusting for confounders. Effect modification by gender was also evaluated. Results: Higher baseline plasma levels of twelve biomarkers were significantly associated with increased NADC risk. The strongest associations were found for PD-L2 (aHR=3.33), PAI-1 (aHR=2.27), and MMP-1 (aHR=2.32). However, a distinct, gender-specific pattern was observed, with significant interactions found for nine biomarkers. Most interactions indicated a higher NADC risk increase in females, with the exception of CD80, TNF-β and IP-10, which indicated a relatively lower risk in females compared to males. Discussion: Plasma biomarkers of immune regulation and SASP are associated with NADC risk in PWH on long-term ART, highlighting the importance of gender-specific pathways in NADC development among PWH. Understanding these distinct profiles may guide future strategies for risk stratification, early detection, and personalized preventive care.
eng
NADCs
PWH
Biomarkers
Gender differences
Immune activation
Senescence
Immune and senescence profiles associated with non-AIDS-defining cancer risk in people with HIV: a case-cohort study.
research article
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