2026-06-14T03:44:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/273462026-03-21T01:15:48Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Zatarain-Nicolás, Eduardo
author
Martín, Pilar
author
Márquez Rodas, Iván
author
Virizuela, Juan
author
Martín García, Ana
author
Mitroi, Cristina
author
Cosín Sales, Juan
author
Barrios, Vivencio
author
Sánchez-Cabo, Fátima
author
Ibañez, Borja
author
de Castro Carpeño, Javier
author
López Fernández, Teresa
2026-03-20T12:49:08Z
2026-03-20T12:49:08Z
2023-11
Clin Transl Oncol. 2023 Nov;25(11):3073-3085
Clinical & Translational Oncology
37227656
https://hdl.handle.net/20.500.12105/27346
Immune checkpoint inhibitors (ICI) have changed the prognosis of many tumors. However, concerning associated cardiotoxicity has been reported. Little is known about the real-life incidence-specific surveillance protocols or the translational correlation between the underlying mechanisms and the clinical presentation of ICI-induced cardiotoxicity. The lack of data from prospective studies led us to review the current knowledge and to present the creation of the Spanish Immunotherapy Registry of Cardiovascular Toxicity (SIR-CVT), a prospective registry of patients receiving ICI that aims to examine the role of hsa-miR-Chr8:96, (a specific serum biomarker of myocarditis) in the early diagnosis of ICI-induced myocarditis. An exhaustive prospective cardiac imaging study will be performed before and during the first 12 months of treatment. The correlation between clinical, imaging, and immunologic parameters may improve our understanding of ICI-induced cardiotoxicity and enable simpler surveillance protocols. We assess ICI-induced cardiovascular toxicity and describe the rationale of the SIR-CVT.
eng
Cardio-oncology
Cardiotoxicity
Immune checkpoint inhibitors
Myocarditis
miRNA
Cardiovascular toxicity of checkpoint inhibitors: review of associated toxicity and design of the Spanish Immunotherapy Registry of Cardiovascular Toxicity.
review
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1331e0e214deac9893a008267b65869f
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Cardiovascular toxicity of checkpoint inhibitors_Clin Transl Oncol_2023.pdf