2026-05-17T14:53:46Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/273282026-04-07T09:38:41Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19613
Repisalud
author
Campos Mena, Sandra
author
Pérez-Gimeno, Gloria
author
Lorusso, Nicola
author
Álvarez Río, Virginia
author
Basile, Luca
author
Batalla Rebollo, Noa
author
García-Comas, Luis
author
Andreu Ivorra, Blanca
author
Pérez-Panadés, Jordi
author
Ramos Marín, Violeta
author
Castrillejo, Daniel
author
Fernández Ibáñez, Ana
author
Rafael de la Cruz López, María Ángeles
author
Nuñez, Olivier
author
Monge Corella, Susana
author
Grupo SiVIRA de vigilancia y efectividad vacunal en España
2026-03-18T18:49:48Z
2026-03-18T18:49:48Z
2025-12-09
Campos Mena S, Pérez-Gimeno G, Lorusso N, et al. Monitoring effectiveness of nirsevimab immunization against RSV hospitalization using surveillance data: a test-negative case–control study, Spain, October 2024–March 2025. Epidemiology and Infection. 2026;154:e5. doi:10.1017/S0950268825100782.
10.1017/S0950268825100782
Epidemiology & Infection
41362152
https://hdl.handle.net/20.500.12105/27328
Effectiveness of nirsevimab against respiratory syncytial virus (RSV) hospitalization during the 2024/2025 season in Spain was estimated using a test-negative design (TND) and hospital-based respiratory infections surveillance data. Children born between 1 April 2024 and 31 March 2025 and hospitalized with severe respiratory infection between the start of the 2024 immunization campaign (regionally variable, between 16 September and 1 October 2024) and 31 March 2025 were systematically RT-PCR RSV-tested within 10 days of symptom onset and classified as cases if positive or controls if negative. Nirsevimab effectiveness ((1 - odds ratio) × 100) was estimated using logistic regression, adjusted for admission week, age, sex, high-risk factors, and regional RSV hospitalization rate. We included 199 cases (68.8% immunized) and 360 controls (86.4% immunized). Overall effectiveness was 65.5% (95% confidence interval: 45.2 to 78.3). Effectiveness was similar among infants born before and after the campaign start (63.6% vs. 70.4%, respectively). We found an unexpected early decrease in effectiveness with increasing time since immunization and age, albeit with wide confidence intervals for some groups. Strong age-period-cohort effects and potential sources of bias were identified, highlighting the need to further explore methodological challenges of implementing the TND in the dynamic population of newborns.
eng
Immunization
Infant
Nirsevimab
Respiratory syncytial virus
Surveillance system
Test-negative design
Monitoring effectiveness of nirsevimab immunization against RSV hospitalization using surveillance data: a test-negative case-control study, Spain, October 2024-March 2025.
research article
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MonitoringEffectivenessNirsevimabImmunization_2025.pdf
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Supplementary_MonitoringEffectivenessNirsevimabImmunization_2025.zip