2026-08-10T08:11:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/272772026-02-28T01:16:21Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991
Repisalud
author
Corman, Alba
author
Sirozh, Oleksandra
author
Lafarga, Vanesa
author
Fernandez-Capetillo, Oscar
2026-02-27T08:11:04Z
2026-02-27T08:11:04Z
2023-03
Trends Biochem Sci . 2023 Mar;48(3):274-287.
Trends Biochem Sci
36229381
https://hdl.handle.net/20.500.12105/27277
The nucleolus is the site of ribosome biogenesis, one of the most resource-intensive processes in eukaryotic cells. Accordingly, nucleolar morphology and activity are highly responsive to growth signaling and nucleolar insults which are collectively included in the actively evolving concept of nucleolar stress. Importantly, nucleolar alterations are a prominent feature of multiple human pathologies, including cancer and neurodegeneration, as well as being associated with aging. The past decades have seen numerous attempts to isolate compounds targeting different facets of nucleolar activity. We provide an overview of therapeutic opportunities for targeting nucleoli in different pathologies and currently available therapies.
eng
RNA Pol I
aging
cancer
drug development
ribosome biogenesis, nucleolar stress
Targeting the nucleolus as a therapeutic strategy in human disease.
research article
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URL
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766268e701918169320d9f0e311fd4dd
3110087
application/pdf
targetingthenucleouls_2022.pdf