2026-08-10T08:12:00Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/272562026-02-23T01:21:42Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991

00925njm 22002777a 4500 dc Casanova-Acebes, Maria author Pitaval, Christophe author Weiss, Linnea A author Nombela-Arrieta, César author Chèvre, Raphaël author A-González, Noelia author Kunisaki, Yuya author Zhang, Dachuan author van Rooijen, Nico author Silberstein, Leslie E author Weber, Christian author Nagasawa, Takashi author Frenette, Paul S author Castrillo, Antonio author Hidalgo, Andrés author 2013-05-23 Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow. We identify a population of CD62L(LO) CXCR4(HI) neutrophils that have "aged" in the circulation and are eliminated at the end of the resting period in mice. Aged neutrophils infiltrate the bone marrow and promote reductions in the size and function of the hematopoietic niche. Modulation of the niche depends on macrophages and activation of cholesterol-sensing nuclear receptors and is essential for the rhythmic egress of hematopoietic progenitors into the circulation. Our results unveil a process that synchronizes immune and hematopoietic rhythms and expand the ascribed functions of neutrophils beyond inflammation. PAPERFLICK: Cell . 2013 May 23;153(5):1025-35. Cell 23706740 https://hdl.handle.net/20.500.12105/27256 STEM-CELL NICHE BONE MARROW G-CSF PROGENITOR CELLS P-SELECTIN INFLAMMATION CXCR4 MOBILIZATION RELEASE MICE Rhythmic modulation of the hematopoietic niche through neutrophil clearance.