2026-05-22T00:15:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/272372026-02-19T01:21:42Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Minguet, Susana
author
Cortegano, Isabel
author
Gonzalo, Pilar
author
Martínez-Marin, José-Alberto
author
de Andrés, Belén
author
Salas, Clara
author
Melero, David
author
Gaspar, Maria-Luisa
author
Marcos, Miguel A R
2026-02-18T13:10:00Z
2026-02-18T13:10:00Z
2003-10
J Clin Invest. 2003 Oct;112(8):1152-63.
14561700
https://hdl.handle.net/20.500.12105/27237
Embryo liver morphogenesis takes place after gastrulation and starts with a ventral foregut evagination that reacts to factor signaling from both cardiac mesoderm and septum transversum mesenchyme. Current knowledge of the progenitor stem cell populations involved in this early embryo liver development is scarce. We describe here a population of 11-day postcoitus c-Kit(low)(CD45/TER119)- liver progenitors that selectively expressed hepatospecific genes and proteins in vivo, was self-maintained in vitro by long-term proliferation, and simultaneously differentiated into functional hepatocytes and bile duct cells. Purified c-Kit(low)(CD45/TER119)- liver cells cocultured with cell-depleted fetal liver fragments engrafted and repopulated the hepatic cell compartments of the latter organoids, suggesting that they may include the embryonic stem cells responsible for liver development.
eng
A population of c-Kit(low)(CD45/TER119)- hepatic cell progenitors of 11-day postcoitus mouse embryo liver reconstitutes cell-depleted liver organoids.
research article
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A population of c-Kit_J Clin Invest_2003.pdf