2026-08-10T08:12:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/272302026-02-17T01:18:23Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991
Repisalud
author
Rivera Calzada, Angel
author
Famelis, Nikolaos
author
Llorca Blanco, Oscar Antonio
author
Geibel, Sebastian
funder
EUROPEAN REGIONAL DEVELOPMENT FUND
funder
INSTITUTO DE SALUD CARLOS III
funder
MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES
2026-02-16T10:14:21Z
2026-02-16T10:14:21Z
2021-09
Nat Rev Microbiol . 2021 Sep;19(9):567-584.
Nature Reviews Microbiology
34040228
https://hdl.handle.net/20.500.12105/27230
Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium tuberculosis, the main causative agent of tuberculosis. Tuberculosis-causing mycobacteria, still accounting for 1.4 million deaths annually, rely on paralogous T7SSs to survive in the host and efficiently evade its immune response. Although it is still unknown how effector proteins of T7SSs cross the outer membrane of the diderm mycobacterial cell envelope, recent advances in the structural characterization of these secretion systems have revealed the intricate network of interactions of conserved components in the plasma membrane. This structural information, added to recent advances in the molecular biology and regulation of mycobacterial T7SSs as well as progress in our understanding of their secreted effector proteins, is shedding light on the inner working of the T7SS machinery. In this Review, we highlight the implications of these studies and the derived transport models, which provide new scenarios for targeting the deathly human pathogen M. tuberculosis.
eng
Type VII secretion systems: structure, functions and transport models.
research article
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URL
https://repisalud.isciii.es/bitstreams/93a0c3bc-be99-434d-9b9c-75b7de717f4f/download
File
MD5
3a8eff65e814e0700f8e58a378865397
3913636
application/pdf
typeVIIsecrectionsystems_2021.pdf