2026-05-22T00:35:33Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/272222026-02-12T01:19:04Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Navas, Alfonso
author
Cobas, Guillermo
author
Talavera, Miguel
author
Ayala, Juan A
author
López, Juan A
author
Martínez, José L
2026-02-11T13:49:24Z
2026-02-11T13:49:24Z
2007-08-21
Proc Natl Acad Sci USA. 2007 Aug 21;104(34):13728-31.
Proceedings of the National Academy of Sciences USA
17699615
https://hdl.handle.net/20.500.12105/27222
A common drawback in evolutionary science is the fact that the evolution of organisms occurs in geological timing, completely out of the time scale of laboratory experimental work. For this reason, some relevant hypotheses on evolution of Metazoans are based on correlations more than on experimental data obtained for testing the robustness of those hypotheses. In the current work, we implement an experimental methodology to analyze the role of infections as a driving force in the evolution of Metazoans (Haldane's hypothesis). To that goal, we have used simple models of virulence with short reproduction times, large populations, and that are easily testable in the laboratory. Using the bacteriovirus nematode Caenorhabditis elegans as a model organism under evolution and their infection by the environmental opportunistic bacterial pathogen Pseudomonas aeruginosa as the selective force, we have demonstrated that bacterial infection selects an evolved nematode lineage resistant to infection, with changes in its respiration and capability of consuming novel food resources. Using an experimental approach, we show that infection is a selective force in the evolution of Metazoans as proposed earlier by Haldane.
eng
Experimental validation of Haldane's hypothesis on the role of infection as an evolutionary force for Metazoans.
research article
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Experimental validation of Haldane's_Proc Natl Acad Sci USA_2007.pdf