2026-08-29T17:24:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/272212026-02-12T01:18:49Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fraga, Mario F
author
Ballestar, Esteban
author
Villar-Garea, Ana
author
Boix-Chornet, Manuel
author
Espada, Jesus
author
Schotta, Gunnar
author
Bonaldi, Tiziana
author
Haydon, Claire
author
Ropero, Santiago
author
Petrie, Kevin
author
Iyer, N Gopalakrishna
author
Pérez-Rosado, Alberto
author
Calvo, Enrique
author
Lopez, Juan A
author
Cano, Amparo
author
Calasanz, Maria J
author
Colomer, Dolors
author
Piris, Miguel Angel
author
Ahn, Natalie
author
Imhof, Axel
author
Caldas, Carlos
author
Jenuwein, Thomas
author
Esteller, Manel
2026-02-11T11:00:41Z
2026-02-11T11:00:41Z
2005-04
Nat Genet. 2005 Apr;37(4):391-400.
Nature Genetics
15765097
https://hdl.handle.net/20.500.12105/27221
CpG island hypermethylation and global genomic hypomethylation are common epigenetic features of cancer cells. Less attention has been focused on histone modifications in cancer cells. We characterized post-translational modifications to histone H4 in a comprehensive panel of normal tissues, cancer cell lines and primary tumors. Using immunodetection, high-performance capillary electrophoresis and mass spectrometry, we found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4. These changes appeared early and accumulated during the tumorigenic process, as we showed in a mouse model of multistage skin carcinogenesis. The losses occurred predominantly at the acetylated Lys16 and trimethylated Lys20 residues of histone H4 and were associated with the hypomethylation of DNA repetitive sequences, a well-known characteristic of cancer cells. Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells.
eng
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
research article
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Loss of acetylation at Lys16 and trimethylation_Nat Genet_2005.pdf