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oai:repisalud.isciii.es:20.500.12105/271882026-01-29T01:19:19Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Severi, Ettore author Georgalis, Leonidas author Pijnacker, Roan author Veneti, Lamprini author Turiac, Iulia Adelina author Chiesa, Flaminia author Rizzo, Caterina author Martinelli, Domenico author Vold, Line author Herrador, Bernardo Guzman author Varela Martinez, Maria del Carmen author Martínez-Sánchez, Elena Vanesa author Semenza, Jan C author Lopalco, Pierluigi author Dahlström, Lisen Arnheim author Giesecke, Johan author 2022-05 Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease. Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of "severe hospitalisations"; and iv) risk factors for severe hospitalisation. Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease. Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. Severi E, Georgalis L, Pijnacker R, Veneti L, Turiac IA, Chiesa F, Rizzo C, Martinelli D, Vold L, Herrador BG, Martinez CV, Sanchez EVM, Semenza JC, Lopalco P, Dahlström LA, Giesecke J. Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014. Int J Infect Dis. 2022 May;118:34-43. doi: 10.1016/j.ijid.2022.01.053. Epub 2022 Feb 5. PMID: 35134558. 10.1016/j.ijid.2022.01.053 International Journal of Infectious Diseases 35134558 https://hdl.handle.net/20.500.12105/27188 Europe Hepatitis A infection Hepatitis A virus Hospitalisation Surveillance Viral hepatitis Severity Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014.