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oai:repisalud.isciii.es:20.500.12105/271742026-01-24T01:20:30Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud author Koni, Aida author Santos-Cuerva, Alvaro author Sotos-Prieto, Mercedes author Ortolá, Rosario author Olmedo, Pablo author García-Pérez, Javier author Ramis, Rebeca author Carballo-Casla, Adrián author Gil, Fernando author González-Palacios, Javier author Pastor-Barriuso, Roberto author Navas Acién, Ana author Plans-Beriso, Elena author Fernandez-Navarro, Pablo L author Rodríguez-Artalejo, Fernando author García-Esquinas, Esther 2026-01-23T11:10:31Z 2026-01-23T11:10:31Z 2026 Koni A, Santos-Cuerva A, Sotos-Prieto M, Ortolá R, Olmedo P, García-Pérez J, Ramis R, Carballo-Casla A, Gil F, González-Palacios J, Pastor-Barriuso R, Navas Acién A, Plans-Beriso E, Fernández-Navarro P, Rodríguez-Artalejo F, García-Esquinas E. Blood-based Lead Biomarkers And Sarcopenia Indicators In Older Adults. Journal of Cachexia, Sarcopenia and Muscle (2026) https://doi.org/10.1002/jcsm.70179. 10.1002/jcsm.70179 2190-6009 2190-5991 Journal of Cachexia, Sarcopenia and Muscle https://hdl.handle.net/20.500.12105/27174 Background: Chronic exposure to low levels of lead (Pb) remains a widespread public health issue, especially among older adults. While its neurotoxic and cardiovascular effects are well recognized, its potential role in accelerating age-related musculoskeletal decline is less understood. Emerging evidence suggests Pb may contribute to sarcopenia, but epidemiological data, especially regarding the most informative biomarkers of exposure, are limited. Methods: We analyzed data from 11,842 participants aged ≥60 years across four population-based studies (NHANES III, NHANES 1999-2006, NHANES 2011-2012 and Seniors-ENRICA-2). Sarcopenia indicators included muscle strength (grip strength and chair stand test), muscle mass (Dual energy X-ray Absorptiometry, calf circumference and arm circumference), and muscle function (gait speed and Short Physical Performance Battery scores). Sarcopenia was defined in the Seniors-ENRICA-2 using the European Working Group on Sarcopenia in Older People 2 criteria. Associations between Pb exposure (serum and whole blood) and sarcopenia indicators were estimated using multivariable regression and meta-analyses. Results: Pb levels were associated with residential environmental exposures such as traffic proximity, industrial emissions, and soil contamination, explaining approximately 11% of variability in whole blood Pb and 9% in serum Pb. Both whole blood and serum Pb showed dose-dependent inverse associations with muscle sarcopenia indicators, including measures of strength, mass, and function. Associations with lower-limb outcomes were generally stronger for serum Pb comparted to whole blood Pb. An interquartile range increase in serum Pb was associated with a 1.33-fold increase in the odds of confirmed or severe sarcopenia (95% CI: 1.02, 1.70), compared to a 1.20-fold increase for whole blood Pb (95% CI: 1.06, 1.36). Conclusions: Environmental Pb exposure is associated with detrimental effects on musculoskeletal health and contributes to sarcopenia in older adults. Serum Pb may be a more sensitive biomarker of musculoskeletal aging than whole blood Pb and should be considered in future research and surveillance strategies. eng Lead Heavy metal Pollution Muscle strength Muscle function Sarcopenia Blood-based Lead Biomarkers And Sarcopenia Indicators In Older Adults research article 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 URL https://repisalud.isciii.es/bitstreams/2b6ad11a-6e06-4524-96a1-a1898e5bd0bd/download File MD5 01f8bcda774d6a171df86e775e464691 646390 application/pdf BloodBasedLeadBiomarkers_2026.pdf