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oai:repisalud.isciii.es:20.500.12105/271732026-01-23T01:16:37Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Fernandez-Rodriguez, Amanda author Berenguer, Juan author Rallón, Norma author Jimenez-Sousa, Maria Angeles author López, Juan Carlos author Soriano, Vicente author Garcia-Alvarez, Monica author Cosín, Jaime author Martínez, Paula author Guzman-Fulgencio, Maria author Miralles, Pilar author Miguel Benito, José author Resino, Salvador author 2014-10-01 Objectives: To analyze whether peroxisome proliferator-activated receptor gamma (PPARγ2) rs1801282 (Pro12Ala) polymorphism is associated with the response to pegylated-interferon-alpha plus ribavirin treatment in HIV/hepatitis C virus (HCV)-coinfected patients, and whether it is able to predict the outcome of HCV treatment. Design: Retrospective follow-up study. Methods: Two hundred eighty-five naive patients, who started HCV-treatment, were genotyped for PPARγ2 and interleukin 28B polymorphisms. Genetic data were analyzed under dominant inheritance model. Sustained virological response (SVR) was defined as undetectable HCV viremia through 24 weeks after the end of HCV treatment. Results: The variables significantly associated with SVR in a multivariate analysis were HCV-genotype (GT) 3 {adjusted odds ratio [aOR] = 7.66 [95% of confidence interval (95% CI): 3.96 to 14.81] P < 0.001}, HCV-viremia <500,000 IU/mL [aOR = 2.20 (95% CI: 1.16 to 4.15] P = 0.015), no/mild liver fibrosis (F < 2) [aOR = 1.92 (95% CI: 1.08 to 3.42) P = 0.026], IL28B rs12980275 AA genotype [aOR = 2.70 (95% CI: 1.54 to 4.71) P < 0.001], and PPARγ2 rs1801282 CG/GG genotype [aOR = 2.93 (95% CI: 1.27 to 6.72) P = 0.011]. When PPARγ2 rs1801282 genotype was included in a decision tree analysis, HCV-GT3 patients with CG/GG genotype had increased SVR from 80.3% to 100%. In GT1/4 patients, rs12980275 AA carriers had increased SVR from 58.7% to 78.6%, and rs12980275 AG/GG carriers had increased SVR from 28.7% to 35.7%. The overall percentage of patients correctly classified was 71.6% and the area under the receiver operating characteristic curves was 0.766 ± 0.028. Conclusions: The presence of PPARγ2 rs1801282 G allele (Ala variant) was associated with increased odds for achieving SVR in HIV/HCV-coinfected patients on HCV treatment. Fernández-Rodríguez, Amanda; Berenguer, Juan MD; Rallón, Norma; Jiménez-Sousa, María A.; López, Juan Carlos; Soriano, Vicente; García-Álvarez, Mónica; Cosín, Jaime MD; Martínez, Paula; Guzmán-Fulgencio, María; Miralles, Pilar; Miguel Benito, José; Resino, Salvador. PPARγ2 Pro12Ala Polymorphism Is Associated With Sustained Virological Response in HIV/HCV-Coinfected Patients Under HCV Therapy. JAIDS Journal of Acquired Immune Deficiency Syndromes 67(2):p 113-119, October 1, 2014. DOI: 10.1097/QAI.0000000000000282. https://hdl.handle.net/20.500.12105/27173 25072612 10.1097/QAI.0000000000000282 Journal of Acquired Immune Deficiency Syndromes Chronic hepatitis C AIDS HCV therapy PPARγ2 Single nucleotide polymorphism PPARγ2 Pro12Ala polymorphism is associated with sustained virological response in HIV/HCV-coinfected patients under HCV therapy.