2026-06-14T03:39:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/271542026-01-17T01:16:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610
Repisalud
author
Pérez-Díaz, Celia
author
Echeverría, Ruth
author
Pérez-Carrascosa, Francisco M.
author
Salcedo-Bellido, Inmaculada
author
Requena, Pilar
author
Barrios-Rodríguez, Rocío
author
Ramos, Juan Jose
author
Olea, Nicolás
author
Fernández, Mariana F.
author
Martín-Olmedo, Piedad
author
Arrebola, Juan Pedro
2026-01-16T21:19:32Z
2026-01-16T21:19:32Z
2025-07
Pérez-Díaz C, Echeverría R, Pérez-Carrascosa FM, Salcedo-Bellido I, Requena P, Barrios-Rodríguez R, Ramos JJ, Olea N, Fernández MF, Martín-Olmedo P, Arrebola JP. Associations of internal persistent organic pollutant levels with sex hormones: An analysis by sex and menopausal status in a Spanish cohort. iScience. 2025 Jun 16;28(7):112876. doi: 10.1016/j.isci.2025.112876. PMID: 40678528; PMCID: PMC12270682.
10.1016/j.isci.2025.112876
2589-0042
iScience
https://hdl.handle.net/20.500.12105/27154
The aim of this study was to investigate associations between human exposure to persistent organic pollutants and sex hormone levels. The study population (n = 253) was a subsample of GraMo adult cohort, recruited in 2003-2004 in two hospitals from Granada, Spain. Exposure was estimated by analyzing samples of adipose tissue (3 organochlorine pesticides and 3 polychlorinated biphenyls) and serum (4 per- and polyfluoroalkyl substances). Data analyses included robust linear regression and weighted quantile sum regression. In men, PFNA (positively) and PCB-138 (negatively) were associated with testosterone. In premenopausal women, OCPs and PCBs were negatively associated with estradiol and SHBG. PFHxS was inversely related to luteinizing hormone. Additionally, PCB-153 and -180 was positively associated with testosterone. The mixture of PCBs/OCPs was positively associated with testosterone in women and with FSH in men. Our results highlight the potential of chemical mixture exposure to alter sex hormone homeostasis, depending on sex and menopausal status.
eng
Environmental health
Environmental science.
Associations of internal persistent organic pollutant levels with sex hormones: An analysis by sex and menopausal status in a Spanish cohort
research article
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URL
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AssociationsInternalPersistentOrganic_2025.pdf
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Supplementary_AssociationsInternalPersistentOrganic_2025.pdf