2026-05-04T00:30:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/271392026-01-13T01:16:53Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Solana, Jose Carlos
author
Moreno, Javier
author
Iborra, Salvador
author
Soto, Manuel
author
Requena, Jose M
2026-01-12T13:26:43Z
2026-01-12T13:26:43Z
2022-04
Solana JC, Moreno J, Iborra S, Soto M, Requena JM. Live attenuated vaccines, a favorable strategy to provide long-term immunity against protozoan diseases. Trends Parasitol. 2022 Apr;38(4):316-334. doi: 10.1016/j.pt.2021.11.004. Epub 2021 Dec 9. PMID: 34896016.
10.1016/j.pt.2021.11.004
Trends in Parasitology
34896016
https://hdl.handle.net/20.500.12105/27139
The control of diseases caused by protozoan parasites is one of the United Nations' Sustainable Development Goals. In recent years much research effort has gone into developing a new generation of live attenuated vaccines (LAVs) against malaria, Chagas disease and leishmaniasis. However, there is a bottleneck related to their biosafety, production, and distribution that slows downs further development. The success of irradiated or genetically attenuated sporozoites against malaria, added to the first LAV against leishmaniasis to be evaluated in clinical trials, is indicative that the drawbacks of LAVs are gradually being overcome. However, whether persistence of LAVs is a prerequisite for sustained long-term immunity remains to be clarified, and the procedures necessary for clinical evaluation of vaccine candidates need to be standardized.
eng
Chagas disease
Attenuated vaccines
Genetically modified parasites
Leishmaniasis
Malaria
Live attenuated vaccines, a favorable strategy to provide long-term immunity against protozoan diseases.
review article
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6019320bd4a152146e400a151004bc5d
1449560
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LiveAttenuatedVaccinesFavorable_2022.pdf