2026-05-17T01:18:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/270972025-12-20T01:18:25Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Yilmaz, Bahtiyar
author
Baertschi, Isabel
author
Meier, Karin H U
author
Le Gac, Constance
author
Jordi, Sebastian B U
author
Black, Caitlin
author
Li, Jiaqi
author
Lindholm, Anna K
author
König, Barbara
author
Sauer, Uwe
author
Stelling, Jörg
author
Macpherson, Andrew J
2025-12-19T13:41:46Z
2025-12-19T13:41:46Z
2025-11-12
Cell Host Microbe. 2025 Nov 12;33(11):1960-1976
Cell Host and Microbe
41187758
https://hdl.handle.net/20.500.12105/27097
Host-microbiota mutualism is rooted in the exchange of dietary and metabolic molecules. Microbial diversity broadens the metabolite pool, with each taxon contributing distinct compounds in varying proportions. In the human microbiome, high variability in consortial composition is largely compensated by similar metabolic functions across different taxa. However, the extent of compensation in lower diversity mouse models, and whether vivaria are metabolically equivalent, is unknown. We provide a searchable resource of microbiome composition variability across 51 murine vivaria and 12 wild mouse colonies worldwide, with vivarium-specific variants mapped according to predicted 3D structures for each microbial species. Our matched metabolomics data show that realized metabolic potential has relatively low variability, providing functional evidence for metabolic compensation. Additionally, variability is related to taxonomic composition rather than vivarium, revealing taxa-metabolite associations that are potentially relevant to phenotypic differences between vivaria. Collectively, this resource offers tools to strengthen microbiome studies and collaborative science.
eng
functional complementation
genome-scale model
metabolomics
metagenomics
sub-strain variants
wild mice microbiota
A global survey of taxa-metabolic associations across mouse microbiome communities.
research article
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URL
https://repisalud.isciii.es/bitstreams/fbfc6821-0acc-480b-a996-9be2516b2d47/download
File
MD5
b41d863706ced85d51e6df638b98a48b
9870804
application/pdf
A global survey of taxa_Cell Host Microbe_2025.pdf