2026-05-17T01:18:39Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/270972025-12-20T01:18:25Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Yilmaz, Bahtiyar author Baertschi, Isabel author Meier, Karin H U author Le Gac, Constance author Jordi, Sebastian B U author Black, Caitlin author Li, Jiaqi author Lindholm, Anna K author König, Barbara author Sauer, Uwe author Stelling, Jörg author Macpherson, Andrew J author 2025-11-12 Host-microbiota mutualism is rooted in the exchange of dietary and metabolic molecules. Microbial diversity broadens the metabolite pool, with each taxon contributing distinct compounds in varying proportions. In the human microbiome, high variability in consortial composition is largely compensated by similar metabolic functions across different taxa. However, the extent of compensation in lower diversity mouse models, and whether vivaria are metabolically equivalent, is unknown. We provide a searchable resource of microbiome composition variability across 51 murine vivaria and 12 wild mouse colonies worldwide, with vivarium-specific variants mapped according to predicted 3D structures for each microbial species. Our matched metabolomics data show that realized metabolic potential has relatively low variability, providing functional evidence for metabolic compensation. Additionally, variability is related to taxonomic composition rather than vivarium, revealing taxa-metabolite associations that are potentially relevant to phenotypic differences between vivaria. Collectively, this resource offers tools to strengthen microbiome studies and collaborative science. Cell Host Microbe. 2025 Nov 12;33(11):1960-1976 Cell Host and Microbe 41187758 https://hdl.handle.net/20.500.12105/27097 functional complementation genome-scale model metabolomics metagenomics sub-strain variants wild mice microbiota A global survey of taxa-metabolic associations across mouse microbiome communities.