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oai:repisalud.isciii.es:20.500.12105/270962025-12-19T01:18:49Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Casulli, Adriano author Abela-Ridder, Bernadette author Petrone, Daniele author Fabiani, Massimo author Bobić, Branko author Carmena, David author Šoba, Barbara author Zerem, Enver author Gargaté, Maria João author Kuzmanovska, Gordana author Calomfirescu, Cristian author Rainova, Iskra author Sotiraki, Smaragda author Lungu, Vera author Dezsényi, Balázs author Herrador, Zaida author Karamon, Jacek author Maksimov, Pavlo author Oksanen, Antti author Millon, Laurence author Sviben, Mario author Shkjezi, Renata author Gjoni, Valbona author Akshija, Ilir author Saarma, Urmas author Torgerson, Paul author Šnábel, Viliam author Antolová, Daniela author Muhovic, Damir author Besim, Hasan author Chereau, Fanny author Belhassen García, Moncef author Chappuis, François author Gloor, Severin author Stoeckle, Marcel author Müllhaupt, Beat author Manno, Valerio author Santoro, Azzurra author Santolamazza, Federica author 2023-03 The neglected zoonosis cystic echinococcosis affects mainly pastoral and rural communities in both low-income and upper-middle-income countries. In Europe, it should be regarded as an orphan and rare disease. Although human cystic echinococcosis is a notifiable parasitic infectious disease in most European countries, in practice it is largely under-reported by national health systems. To fill this gap, we extracted data on the number, incidence, and trend of human cases in Europe through a systematic review approach, using both the scientific and grey literature and accounting for the period of publication from 1997 to 2021. The highest number of possible human cases at the national level was calculated from various data sources to generate a descriptive model of human cystic echinococcosis in Europe. We identified 64 745 human cystic echinococcosis cases from 40 European countries. The mean annual incidence from 1997 to 2020 throughout Europe was 0·64 cases per 100 000 people and in EU member states was 0·50 cases per 100 000 people. Based on incidence rates and trends detected in this study, the current epicentre of cystic echinococcosis in Europe is in the southeastern European countries, whereas historical endemic European Mediterranean countries have recorded a decrease in the number of cases over the time. Casulli A, Abela-Ridder B, Petrone D, Fabiani M, Bobić B, Carmena D, Šoba B, Zerem E, Gargaté MJ, Kuzmanovska G, Calomfirescu C, Rainova I, Sotiraki S, Lungu V, Dezsényi B, Herrador Z, Karamon J, Maksimov P, Oksanen A, Millon L, Sviben M, Shkjezi R, Gjoni V, Akshija I, Saarma U, Torgerson P, Šnábel V, Antolová D, Muhovic D, Besim H, Chereau F, Belhassen García M, Chappuis F, Gloor S, Stoeckle M, Müllhaupt B, Manno V, Santoro A, Santolamazza F. Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project. Lancet Infect Dis. 2023 Mar;23(3):e95-e107. doi: 10.1016/S1473-3099(22)00638-7. Epub 2022 Nov 22. PMID: 36427513. 10.1016/s1473-3099(22)00638-7 Lancet Infectious Diseases 36427513 https://hdl.handle.net/20.500.12105/27096 Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project.